Serum miR-30e and miR-223 as Novel Noninvasive Biomarkers for Hepatocellular Carcinoma.

The American Journal of Pathology
Sourav BhattacharyaRatna B Ray

Abstract

Hepatocellular carcinoma (HCC) is one of the most aggressive cancers and is the third leading cause of all cancer-related death. Limited noninvasive biomarkers are available for HCC detection. Early detection is the key in improving the survival of HCC patients. In this study, we tested the hypothesis that serum miRNAs can be used as a potential biomarker for HCC. Quantitative RT-PCR for miRNA analysis was performed using 70 serum samples. Receiver operating characteristic analysis was performed to measure the prognostic power of the miRNAs. The miRNA expression level was also measured from liver biopsy samples. Our study revealed that two miRNAs, miR-30e and miR-223, were expressed at significantly lower levels (P < 0.003) in the sera of HCC patients compared with healthy volunteers. Furthermore, expression of these miRNAs was compared between sera from chronic liver disease and sera from HCC patients. miR-30e and miR-223 expression was significantly lower in HCC sera compared with sera from chronic liver disease patients. Both miRNA expression levels were lower in HCC liver biopsy specimens compared with normal liver RNA. Taken together, our results suggested that serum miR-30e and miR-223 are useful biomarkers of HCC, irresp...Continue Reading

References

Feb 20, 2003·RNA·Victor AmbrosThomas Tuschl
Jan 17, 2008·Nature Reviews. Genetics·Witold FilipowiczNahum Sonenberg
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thian-Sze WongWilliam Ignace Wei
Feb 3, 2009·Gastroenterology·Nicholas J HandJoshua R Friedman
Feb 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kai WangDavid J Galas
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Jan C BraseHolger Sültmann
Nov 30, 2010·Molecular Cancer·Jan C BraseHolger Sültmann
Jan 26, 2011·Annals of Surgery·Nuh N RahbariJürgen Weitz
Oct 14, 2011·The New England Journal of Medicine·Hashem B El-Serag
Nov 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Philip J Starkey LewisB Kevin Park
Nov 11, 2011·PloS One·Cheng You JiaXing Zhong Wu
Jan 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruiqun QiQing-Sheng Mi
Mar 20, 2012·Molecular Medicine Reports·Xianfeng DingQuan Du
Oct 20, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Silvia Giordano, Amedeo Columbano
Oct 23, 2012·Journal of Hepatology·Jonel TrebickaMargarete Odenthal
Feb 8, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shubham ShrivastavaRatna B Ray
Aug 9, 2013·Experimental Biology and Medicine·Tao YangXian-Bo Zhang
May 20, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hashem B El-Serag, Fasiha Kanwal
Sep 16, 2014·Advanced Drug Delivery Reviews·Guofeng Cheng
Sep 19, 2014·World Journal of Gastroenterology : WJG·Han-Shao Liu, Hua-Sheng Xiao
Apr 29, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiaolong TuJunfeng Zhang
May 1, 2015·Cell Cycle·Kewei Wang
Jun 10, 2015·British Journal of Cancer·F D'AiutoM G Daidone

❮ Previous
Next ❯

Citations

Apr 6, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xu ZhouJun Lu
Apr 30, 2016·International Journal of Molecular Sciences·Erika LarreaCharles H Lawrie
Jan 18, 2018·International Journal of Molecular Sciences·Florian SchuellerChristoph Roderburg
Feb 28, 2019·Archives of Gynecology and Obstetrics·Seyed Omar Ebrahimi, Somayeh Reiisi
Mar 12, 2019·Biomarkers in Medicine·Weronika Zofia ŚwitlikJanusz Szemraj
Jun 25, 2017·Clinical Science·Florian SchuellerChristoph Roderburg
Nov 7, 2019·Journal of Clinical Laboratory Analysis·Guopan YuDan Xu
Dec 12, 2018·Journal of Cellular Physiology·Javid Sadri NahandHossein Keyvani
Oct 14, 2016·World Journal of Surgical Oncology·Keli SuGuijun Hao
Dec 25, 2019·BioMed Research International·Yao JiangHualin Tao
Jul 25, 2019·Hepatology Communications·Reina SasakiRatna B Ray
Mar 31, 2018·International Journal of Molecular Sciences·Francesca PezzutoMaria Lina Tornesello
Sep 28, 2018·Experimental & Molecular Medicine·Dan YeYanning Liu
May 24, 2019·Frontiers in Pharmacology·Gulcin TezcanSvetlana F Khaiboullina
May 19, 2020·British Journal of Biomedical Science·A AbdeltawabS M Zaied
Oct 6, 2020·Journal of Immunology Research·Liliana R BalahuraMarieta Costache
Oct 21, 2017·Journal of Experimental & Clinical Cancer Research : CR·Xian QinQuan-Yan Liu
Nov 28, 2020·European Journal of Clinical Investigation·Amir Hossein AalamiAmirhossein Sahebkar
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qin HuangJing Yang
Dec 22, 2016·Biochemical and Biophysical Research Communications·Zheng DongYinying Lu
May 6, 2021·Wiley Interdisciplinary Reviews. RNA·Andrea FaveroBarbara Belletti
Nov 17, 2021·Biomarkers in Medicine·Zhuo HanJianying Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.