Serum miRNAs miR-140-3p and miR-23b-3p as potential biomarkers for osteoporosis and osteoporotic fracture in postmenopausal Mexican-Mestizo women

Gene
Eric G Ramírez-SalazarRafael Velázquez-Cruz

Abstract

Osteoporosis is a metabolic bone disorder characterized by low bone mineral density and decreased bone strength, leading to an increased risk of fractures with a consequent increase in morbidity and mortality. The current methods to estimate the fracture risk are very limited. microRNAs (miRNAs) have been considered as good biomarkers for many pathological processes, including osteoporosis. Some circulating miRNAs are associated with regulation of bone formation and differentiation of bone cells. The aim of this study, was to analyze the expression of miRNAs in serum of patients with osteoporosis (n = 20) and healthy controls (n = 20). Expression of 754 miRNAs was analyzed through quantitative real time RT-PCR arrays. Seven miRNAs showed significant differences between groups. The microRNAs miR-23b-3p, miR-140-3p and miR-885-5p were selected based on fold change and p-values (40.5, p = 0.038, 20.7, p = 0.045, and 2.2, p = 0.002; respectively) for validation in independent serum samples from patients with osteopenia (n = 28), osteoporosis (n = 26) and osteoporotic hip fracture (n = 21). After validation, we confirm differences across the groups for miR-23b-3p and miR-140-3p. Our data pointed miR-140-3p and miR-23b-3p as potentia...Continue Reading

Citations

Mar 14, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael Hadjiargyrou, David E Komatsu
May 31, 2019·Cellular and Molecular Life Sciences : CMLS·Daniele BellaviaG Giavaresi
Nov 7, 2019·Journal of Cellular Biochemistry·Yi DaiHao Li
Jun 24, 2020·Biomolecules·Simone DonatiMaria Luisa Brandi
Aug 18, 2020·BioMed Research International·Hiroaki NakashimaShiro Imagama
Sep 25, 2020·International Journal of Molecular Sciences·Simone CiuffiMaria Luisa Brandi
Dec 2, 2020·International Journal of Molecular Sciences·Massimo De MartinisSebastiano Gangemi
Dec 11, 2020·Bone·Johannes GrillariMatthias Hackl
Feb 11, 2021·In Vitro Cellular & Developmental Biology. Animal·Jian-Zhong Wang, Bao-Hui Zhao
Jun 3, 2021·International Journal of Molecular Sciences·Yen-Zung WuChung-Hwan Chen

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