Serum MUC5AC mucin as a potential marker for cholangiocarcinoma

Cancer Letters
Sopit WongkhamVajarabhongsa Bhudhisawasdi

Abstract

Aberrant expression of MUC5AC mucin is obvious in cholangiocarcinoma tissues, however, this mucin has never been detected in the serum. Using immunoblotting marked with antibody vs. MUC5AC core protein, we could detect MUC5AC mucin in the serum of 112 from 179 cholangiocarcinoma patients (62.6% sensitivity), two of the 62 with benign hepatobiliary diseases, six of the 60 with hepato-gastrointestinal cancer, and none in either the 60 active opisthorchiasis or 74 healthy persons. Detection of serum mucin in the serum of cholangiocarcinoma patients corresponded well to the MUC5AC expressed in individual tissues. Serum MUC5AC may be used to enhance the diagnostic accuracy of cholangiocarcinoma.

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Citations

Dec 17, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sopit WongkhamPeti Thuwajit
Jun 10, 2004·Current Opinion in Oncology·David MalkaMichel Ducreux
Jun 13, 2006·The Journal of Clinical Investigation·Xiaoling XuChu-Xia Deng
Dec 14, 2006·Critical Reviews in Oncology/hematology·Melanie B Thomas
May 27, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M Grunnet, M Mau-Sørensen
Aug 27, 2013·Expert Opinion on Medical Diagnostics·James R A SkipworthStephen P Pereira
May 1, 2008·Expert Opinion on Medical Diagnostics·Priya RupeshShukla Vijay Kumar
Nov 16, 2017·Journal of Gastrointestinal Cancer·Noel PabalanVeerachai Thitapakorn
May 14, 2008·British Journal of Cancer·W R MatullS P Pereira
Sep 26, 2003·Cancer·Chanchai BoonlaChawalit Pairojkul
Mar 17, 2019·International Journal of Molecular Sciences·Aldona Kasprzak, Agnieszka Adamek
Nov 16, 2016·The American Journal of Gastroenterology·Sukhwinder KaurSurinder K Batra
Aug 27, 2005·World Journal of Gastroenterology : WJG·Chanchai BoonlaSopit Wongkham

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