Serum N-glycan analysis in breast cancer patients--Relation to tumour biology and clinical outcome

Molecular Oncology
Vilde D HaakensenZohar Yakhini

Abstract

Glycosylation and related processes play important roles in cancer development and progression, including metastasis. Several studies have shown that N-glycans have potential diagnostic value as cancer serum biomarkers. We have explored the significance of the abundance of particular serum N-glycan structures as important features of breast tumour biology by studying the serum glycome and tumour transcriptome (mRNA and miRNA) of 104 breast cancer patients. Integration of these types of molecular data allows us to study the relationship between serum glycans and transcripts representing functional pathways, such as metabolic pathways or DNA damage response. We identified tri antennary trigalactosylated trisialylated glycans in serum as being associated with lower levels of tumour transcripts involved in focal adhesion and integrin-mediated cell adhesion. These glycan structures were also linked to poor prognosis in patients with ER negative tumours. High abundance of simple monoantennary glycan structures were associated with increased survival, particularly in the basal-like subgroup. The presence of circulating tumour cells was found to be significantly associated with several serum glycome structures like bi and triantennary,...Continue Reading

References

Jan 1, 1992·Statistical Methods in Medical Research·D J Hand
Dec 1, 1996·The Biochemical Journal·S EatonM Pourfarzam
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Feb 5, 2002·Annual Review of Physiology·Piero RinaldoMichael J Bennett
Dec 19, 2002·Journal of the American Dietetic Association·Java O Solis, Rani H Singh
Sep 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G WiedswangB Naume
Mar 16, 2005·Cell·Steven M JohnsonFrank J Slack
Aug 17, 2005·Cancer Research·Marilena V IorioCarlo M Croce
Nov 16, 2005·International Journal of Cancer. Journal International Du Cancer·Gro WiedswangBjørn Naume
Dec 17, 2008·Journal of Proteome Research·Chen LiDavid M Lubman
Mar 19, 2009·British Journal of Cancer·A H OlsenE Lynge
Dec 4, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R SaldovaM Cristofanilli
Mar 3, 2011·PloS One·Espen EnerlyAnne-Lise Børresen-Dale
Apr 22, 2011·Nature Reviews. Cancer·Willem H KoppenolChi V Dang
Nov 19, 2011·Nucleic Acids Research·Thomas KelderAlexander R Pico
Mar 1, 2012·Molecular & Cellular Proteomics : MCP·Zhenqi ZhouYuchun Du
Feb 1, 2013·Molecular & Cellular Proteomics : MCP·L Renee RuhaakCarlito B Lebrilla
Feb 13, 2013·Molecular & Cellular Proteomics : MCP·Kevin Chandler, Radoslav Goldman
Dec 19, 2013·Mass Spectrometry·Carlito B Lebrilla
Apr 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D S M ChanT Norat
Feb 7, 2015·Molecular Oncology·Ivan O PotapenkoVilde D Haakensen

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Citations

Mar 19, 2016·Biochimica Et Biophysica Acta·Andreia Almeida, Daniel Kolarich
Oct 1, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Gordon GrevilleRadka Saldova
Jun 29, 2017·Molecular Oncology·Radka SaldovaPauline M Rudd
Sep 25, 2018·Electrophoresis·Djuro JosicKresimir Pavelic
Nov 2, 2019·Scientific Reports·Alexander GolbergZohar Yakhini
May 22, 2019·Frontiers in Oncology·Tereza DědováVéronique Blanchard
Mar 8, 2019·Interface Focus·Hannah J Lomax-BrowneMiriam V Dwek
Oct 22, 2020·Molecular & Cellular Proteomics : MCP·Fanny BoyavalBram Heijs
Feb 14, 2021·Molecular & Cellular Proteomics : MCP·Fanny BoyavalBram Heijs
Mar 20, 2019·Journal of Proteome Research·Qinying LiGuangli Yu

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