Serum Neuregulin-1beta as a Biomarker of Cardiovascular Fitness.

The Open Biomarkers Journal
Vaibhav MoondraDouglas B Sawyer

Abstract

PURPOSE: Neuregulins (NRG) are growth factors that bind to receptors of the erbB family, and are known to mediate a number of processes involved in diverse tissues. Neuregulin-1beta is expressed in skeletal muscle and is activated by exercise. We hypothesized that NRG-1beta might circulate in the bloodstream and increase as a consequence of physical activity. A study was conducted in healthy subjects to determine if NRG-1beta is immunodetectable in human serum, and if so whether levels relate acutely or chronically to exercise. METHODS: Nine healthy men underwent three bouts of exercise of varying degrees of intensity on a bicycle ergometer over a period of three weeks. Cardio-respiratory fitness was determined by measurement of maximal oxygen uptake (VO(2)max). Serum was sampled prior to and immediately after each session (up to 30 minutes post) and serum NRG-1beta was quantified utilizing an indirect sandwich ELISA assay developed in our lab. RESULTS: Across subjects, mean serum NRG-1beta levels ranged from 32 ng/mL to 473 ng/mL. Individual subjects showed relatively stable levels during the study period that did not change acutely after exercise. Serum NRG-1beta demonstrated a positive correlation with VO(2)max (r2=0.49, p =...Continue Reading

Citations

Nov 16, 2013·Current Heart Failure Reports·Cristi L GalindoDouglas B Sawyer
Apr 1, 2014·Current Heart Failure Reports·Carrie Geisberg Lenneman
Jul 7, 2011·Journal of Molecular and Cellular Cardiology·Douglas B Sawyer, Anthony Caggiano
Jul 26, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Mohammed Andaleeb ChowdhuryLijun C Liu
Jul 12, 2018·Circulation. Heart Failure·Amanda J Favreau-LessardSanjeev A Francis
Oct 30, 2012·Circulation Research·Oghenerukevwe OdieteDouglas B Sawyer
Apr 24, 2014·Journal of the American Heart Association·Virginia Shalkey HahnBonnie Ky
Dec 19, 2015·Toxicological and Environmental Chemistry·Ijeoma Favour Vincent-AkpuGillian Mackinnon
Jan 18, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Radwan N SafaDouglas B Sawyer
Dec 31, 2015·American Journal of Physiology. Endocrinology and Metabolism·Iliana López-SoldadoAnna Gumà

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