Serum neurofilament levels reflect outer retinal layer changes in multiple sclerosis.

Therapeutic Advances in Neurological Disorders
Caspar B SeitzVinzenz Fleischer

Abstract

Serum neurofilament light chain (sNfL) and distinct intra-retinal layers are both promising biomarkers of neuro-axonal injury in multiple sclerosis (MS). We aimed to unravel the association of both markers in early MS, having identified that neurofilament has a distinct immunohistochemical expression pattern among intra-retinal layers. Three-dimensional (3D) spectral domain macular optical coherence tomography scans and sNfL levels were investigated in 156 early MS patients (female/male: 109/47, mean age: 33.3 ± 9.5 years, mean disease duration: 2.0 ± 3.3 years). Out of the whole cohort, 110 patients had no history of optic neuritis (NHON) and 46 patients had a previous history of optic neuritis (HON). In addition, a subgroup of patients (n = 38) was studied longitudinally over 2 years. Support vector machine analysis was applied to test a regression model for significant changes. In our cohort, HON patients had a thinner outer plexiform layer (OPL) volume compared to NHON patients (B = -0.016, SE = 0.006, p = 0.013). Higher sNfL levels were significantly associated with thinner OPL volumes in HON patients (B = -6.734, SE = 2.514, p = 0.011). This finding was corroborated in the longitudinal subanalysis by the association of hi...Continue Reading

References

Jan 1, 1981·American Journal of Ophthalmology·B R StraatsmaG N Taylor
Oct 26, 1999·Progress in Retinal and Eye Research·D M Dacey
Oct 16, 2002·The Journal of Comparative Neurology·Béla Völgyi, Stewart A Bloomfield
Jan 21, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Jonatan SalzerPeter Sundström
Oct 19, 2011·Brain : a Journal of Neurology·Stephanie B SycPeter A Calabresi
Apr 27, 2012·PloS One·Prejaas TewarieAxel Petzold
Jan 30, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·L J BalkA Petzold
Jun 21, 2014·Multiple Sclerosis : Clinical and Laboratory Research·S SchipplingA Petzold
Jul 2, 2014·Progress in Retinal and Eye Research·Mrinalini HoonRachel O L Wong
Jan 7, 2015·Annals of Neurology·Iñigo GabilondoPablo Villoslada
Jan 9, 2015·Cell and Tissue Research·Benoit J GentilHeather D Durham
Jul 26, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Omar A Al-LouziShiv Saidha
Aug 19, 2015·Multiple Sclerosis : Clinical and Laboratory Research·S ModvigJ L Frederiksen
May 5, 2016·Journal of Neurology·Lisanne J BalkAri J Green
May 27, 2016·Neurology·Andrés Cruz-HerranzUNKNOWN IMSVISUAL consortium
Aug 16, 2016·Neurology·Georgina ArrambideMar Tintore
Sep 2, 2016·Brain : a Journal of Neurology·Benjamin KnierThomas Korn
May 18, 2017·Annals of Neurology·Giulio DisantoUNKNOWN Swiss Multiple Sclerosis Cohort Study Group
Jul 4, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Bernardo Sanchez-DalmauPablo Villoslada
Sep 19, 2017·Lancet Neurology·Axel PetzoldUNKNOWN ERN-EYE IMSVISUAL
Dec 23, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A Tejeda-VelardeL M Villar
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen
Mar 16, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Nelly SillerStefan Bittner
Aug 4, 2018·Journal of Neurology·Caspar B SeitzVinzenz Fleischer
Sep 2, 2018·Nature Reviews. Neurology·Michael KhalilJens Kuhle
Dec 20, 2018·Annals of Clinical and Translational Neurology·Tanuja ChitnisJens Kuhle
Mar 9, 2019·Brain : a Journal of Neurology·Frédéric LondonOlivier Outteryck
Mar 28, 2019·Frontiers in Neurology·Katharina BirknerStefan Bittner
Aug 28, 2019·Neurology. Neuroimmunology and Neuroinflammation·Maria CellerinoMatilde Inglese
Nov 2, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Gabriel BstehThomas Berger
Apr 15, 2020·Annals of Neurology·Elias S SotirchosUNKNOWN International Multiple Sclerosis Visual System (IMSVISUAL) Consortium
Oct 18, 2020·Annals of Neurology·Christian CordanoAri J Green
Oct 18, 2020·Annals of Neurology·Elias S SotirchosShiv Saidha
Dec 9, 2020·Multiple Sclerosis and Related Disorders·C BridelC E Teunissen

❮ Previous
Next ❯

Software Mentioned

Heidelberg Eye Explorer HEYEX
Heidelberg Eye Explorer
SPSS
Spectralis Viewing Module

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.