Serum neurofilament light chain is increased in hereditary spastic paraplegias

Annals of Clinical and Translational Neurology
Carlo WilkeMatthis Synofzik

Abstract

Blood biomarkers are still largely missing in hereditary spastic paraplegias (HSPs). We here explored Neurofilament light chain (NfL) as a biomarker in HSP. Serum NfL was assessed in 96 HSP (63 genetically confirmed), 96 healthy control, and 33 ALS subjects by single molecule array (Simoa). Compared to controls, NfL was increased in HSP (P < 0.001), correlating with cross-sectional disease progression (ρ = 0.28). Levels were lower than in ALS (P < 0.001), allowing to differentiate HSP from ALS (AUC = 0.91). Serum NfL might serve as a biomarker in HSP indicating neuronal damage and, if confirmed longitudinally, disease progression. It might also support differentiating HSP from ALS.

References

Aug 15, 2015·Annals of Clinical and Translational Neurology·Ricarda A L MenkeMartin R Turner
Feb 10, 2016·Annals of Neurology·Rebecca SchüleLudger Schöls
May 18, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·Carlo WilkeMatthis Synofzik
Feb 10, 2017·Neurology·Oskar HanssonUNKNOWN Swedish BioFINDER study
May 18, 2017·Annals of Neurology·Giulio DisantoUNKNOWN Swiss Multiple Sclerosis Cohort Study Group
Oct 20, 2017·Neurology·Thomas GattringerMichael Khalil
Nov 11, 2017·Brain : a Journal of Neurology·Ludger SchölsRebecca Schüle
Dec 12, 2017·Brain : a Journal of Neurology·Cecilia MarelliFanny Mochel

❮ Previous
Next ❯

Citations

Feb 1, 2020·Journal of Neurology·Stefanie Nicole HayerUNKNOWN EFACTS study group
Oct 14, 2020·Annals of Clinical and Translational Neurology·Wouter J C van BallegoijMarc Engelen
Dec 20, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Elina MillereViktorija Kenina
Apr 1, 2021·Scientific Reports·Tim W RattayDirk Wildgruber
Apr 6, 2021·Annals of Clinical and Translational Neurology·Christoph KesslerRebecca Schüle
Aug 18, 2021·Current Opinion in Neurobiology·Frédéric DariosAlexandra Durr
Oct 17, 2020·Molecular Neurodegeneration·Elisabetta ZucchiJessica Mandrioli
Nov 15, 2018·Neuro-degenerative Diseases·Elisabetta ZucchiJessica Mandrioli
Dec 8, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Giacomo SferruzzaNilo Riva

❮ Previous
Next ❯

Software Mentioned

Simoa

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Related Papers

The Ceylon Medical Journal
Udaya Ranawaka
Seminars in Neurology
A E Harding
Multiple Sclerosis : Clinical and Laboratory Research
Heidi HögelLaura Airas
© 2022 Meta ULC. All rights reserved