Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease.

Neurobiology of Disease
Stephanie A SchultzDominantly Inherited Alzheimer Network

Abstract

Neurofilament light chain (NfL) is a protein that is selectively expressed in neurons. Increased levels of NfL measured in either cerebrospinal fluid or blood is thought to be a biomarker of neuronal damage in neurodegenerative diseases. However, there have been limited investigations relating NfL to the concurrent measures of white matter (WM) decline that it should reflect. White matter damage is a common feature of Alzheimer's disease. We hypothesized that serum levels of NfL would associate with WM lesion volume and diffusion tensor imaging (DTI) metrics cross-sectionally in 117 autosomal dominant mutation carriers (MC) compared to 84 non-carrier (NC) familial controls as well as in a subset (N = 41) of MC with longitudinal NfL and MRI data. In MC, elevated cross-sectional NfL was positively associated with WM hyperintensity lesion volume, mean diffusivity, radial diffusivity, and axial diffusivity and negatively with fractional anisotropy. Greater change in NfL levels in MC was associated with larger changes in fractional anisotropy, mean diffusivity, and radial diffusivity, all indicative of reduced WM integrity. There were no relationships with NfL in NC. Our results demonstrate that blood-based NfL levels reflect WM int...Continue Reading

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Citations

Dec 10, 2020·Neurology. Neuroimmunology and Neuroinflammation·Maija SarasteLaura Airas
Apr 17, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Katherine J BangenUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 24, 2021·Journal of the International Neuropsychological Society : JINS·Breton M AskenKaitlin B Casaletto

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Methods Mentioned

BETA
blood draw
Single

Software Mentioned

FSL
dtifit
FMRIB
R
FMRIB58
Diffusion Toolbox
SPM
Randomise
TBSS
lmerTest

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