Serum Neurofilament Light Predicts Severity and Prognosis in Patients with Ischemic Stroke

Neurotoxicity Research
Peng WangShanji Nan

Abstract

Serum neurofilaments are markers of axonal injury. We investigated whether serum neurofilament light (sNfL) is a potential prognostic marker of functional outcome in Chinese patients with acute ischemic stroke (AIS). From May 2015 to December 2018, consecutive patients with AIS from the Department of Neurology of the Second Hospital of Jilin University were included. sNfL concentration was tested at baseline, and stroke severity was analyzed at admission using the NIHSS score. Functional outcome was assessed at discharge by the modified Rankin scale (mRS). The sNfL concentration was tested in 343 patients with a median value of 17.8 (IQR, 13.4-25.2) pg/ml. sNfL concentration paralleled lesion size (P = 0.035). At admission, 174 patients were defined as moderate-to-high stroke (NIHSS ≥ 5); the sNfL concentration in those patients were higher than that observed in patients with minor clinical severity [21.2 (IQR, 15.1-31.7) vs. 14.9 (11.8-19.4) pg/ml, P < 0.001]. For each 1 quartile increase of sNfL concentration, the unadjusted and adjusted risk of moderate-to-high stroke increased by 202% (with the OR of 3.04 (95% CI 2.15-4.32), P < 0.001) and 102% [2.02 (1.10-3.16), P = 0.001), respectively. At discharge, 85 patients (24.8%) h...Continue Reading

References

Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottM Walker
Dec 9, 2008·Journal of Neuroimmunology·Jun YanPamela A McCombe
Dec 26, 2009·Annals of Neurology·Mira KatanMirjam Christ-Crain
Feb 26, 2011·Journal of the Neurological Sciences·P SinghP A McCombe
Apr 23, 2011·Lancet Neurology·Richard MacrezDenis Vivien
Jul 28, 2011·Neurochemical Research·Johann SellnerAxel Petzold
May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Devin M BarryMichael L Garcia
May 9, 2013·Stroke; a Journal of Cerebral Circulation·Ralph L SaccoUNKNOWN Council on Nutrition, Physical Activity and Metabolism
Jun 18, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Jens KuhleSteven Casha
Feb 19, 2016·Stroke; a Journal of Cerebral Circulation·Amelia K BoehmeMitchell S V Elkind
Apr 5, 2016·Annals of Clinical and Translational Neurology·Julio C RojasAdam L Boxer
Feb 10, 2017·Neurology·Oskar HanssonUNKNOWN Swedish BioFINDER study
May 18, 2017·Annals of Neurology·Giulio DisantoUNKNOWN Swiss Multiple Sclerosis Cohort Study Group
May 27, 2017·Brain : a Journal of Neurology·Grégory KuchcinskiThomas Tourdias
Oct 20, 2017·Neurology·Thomas GattringerMichael Khalil
Dec 28, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G M De MarchisL H Bonati
Mar 16, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Nelly SillerStefan Bittner
Oct 13, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Federico VerdeMarkus Otto
Nov 2, 2018·JAMA Neurology·Marion Moseby-KnappeTobias Cronberg
Jan 2, 2019·Neuroscience Letters·Fani Pujol-CalderónKina Höglund
May 30, 2019·Stroke; a Journal of Cerebral Circulation·Frederick K KorleyDeborah Levine
Jun 4, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Juha OnatsuMikko Taina
Jul 16, 2019·Journal of Neuropathology and Experimental Neurology·Mahsa MayeliFarzaneh Rahmani
Aug 4, 2019·Journal of Neurology·Annie PedersenChristina Jern
Aug 14, 2019·Bioanalysis·Robert HendricksSaloumeh K Fischer
Sep 9, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Claus Vinter Bodker HviidTina Parkner
Sep 14, 2019·JAMA Neurology·Kjetil BjornevikAlberto Ascherio

❮ Previous
Next ❯

Citations

Nov 13, 2020·Science Translational Medicine·Tania F GendronLeonard Petrucelli

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.