Serum Neutrophil Gelatinase B-associated Lipocalin and Matrix Metalloproteinase-9 Complex as a Surrogate Marker for Mucosal Healing in Patients with Crohn's Disease

Journal of Crohn's & Colitis
Magali de BruynGhislain Opdenakker

Abstract

Although costly and uncomfortable for the patient, the current standard to assess mucosal healing in Crohn's disease [CD] patients is endoscopy. The aim of this study was to evaluate NGAL-MMP-9 as surrogate marker for mucosal healing in CD patients. Serum NGAL-MMP-9 levels were determined with sandwich enzyme-linked immunosorbent assay before and up to 5 years after first infliximab infusion in 108 active CD patients [median age at first infliximab 36 years, 57% female] and 43 healthy controls [HC, median age 27 years, 60% female]. Serum samples were matched to the time of endoscopy and complete endoscopic healing was defined as absence of ulcerations. Histological healing was defined as absence of epithelial damage [D'Haens score]. At baseline, median [interquartile range] NGAL-MMP-9 levels were significantly higher in active CD patients vs HC (77.6 [36.9-141.0] vs 25.5 [17.8-42.8] ng/ml; p < 0.001). After treatment, NGAL-MMP-9 levels significantly decreased in completely healed CD patients [n = 38] (84.5 [36.7-138.4] to 23.4 [7.4-42.5] ng/ml; p < 0.001) and--to a lesser extent--in non-healed CD patients [n = 36] (100.9 [43.4-152.6] to 43.8 [27.0-96.8] ng/ml; p = 0.001). Receiver operating characteristic analysis defined a NGA...Continue Reading

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Citations

Jul 28, 2016·Cellular and Molecular Gastroenterology and Hepatology·Vishal SinghMatam Vijay-Kumar
Oct 25, 2016·Critical Reviews in Biochemistry and Molecular Biology·Magali de BruynGhislain Opdenakker
Sep 10, 2016·Scandinavian Journal of Gastroenterology·Daniel MuthasMark Berner Hansen
Sep 20, 2016·Journal of Gastroenterology and Hepatology·Silje ThorsvikArne Kristian Sandvik
Apr 4, 2017·Journal of Crohn's & Colitis·Carolijn SmidsEllen G van Lochem
Feb 26, 2016·World Journal of Gastrointestinal Pathophysiology·Marcello CintoloWalter Fries
Jun 6, 2018·Cell and Tissue Research·Silje ThorsvikArne Kristian Sandvik
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Mar 16, 2019·Expert Review of Clinical Immunology·Jun KatoSakiko Hiraoka
Jun 6, 2020·Diagnostics·Małgorzata Krzystek-KorpackaKatarzyna Neubauer
Oct 23, 2019·Therapeutic Advances in Gastroenterology·Doron YablecovitchShomron Ben-Horin
Oct 7, 2019·Inflammatory Bowel Diseases·Olga Maria NardoneMarietta Iacucci
Feb 23, 2020·Annals of Nuclear Medicine·João Batista Monteiro TajraLiliana Moscoso Ribeiro
May 18, 2020·International Immunopharmacology·Tingting ZhangJie Wu
Oct 24, 2020·Clinical and Translational Gastroenterology·Wouter T van HaaftenGerard Dijkstra
Jun 20, 2020·Journal of Crohn's & Colitis·Andreas ZollnerAlexander R Moschen

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