Serum NUCB2/nesfatin-1 levels in different stages of alcohol dependence: Is there a relationship with craving?

Indian Journal of Psychiatry
Gokhan UmutNesrin Karamustafalioglu

Abstract

In the literature, the relationship between appetite regulating peptides and alcohol craving is on the debate. This study aims to investigate serum level of NUCB2/nesfatin-1, which is discovered as appetite-related neuropeptide, in patients with alcohol dependence who were in craving and abstaining phase and to compare with healthy controls. Research, Treatment, and Training Center for Alcohol and Substance Dependence, (AMATEM) Bakirkoy Training and Research Hospital for Psychiatry Neurology and Neurosurgery, Istanbul, case-control and prospective study design were used. Chi-square, Mann-Whitney U, paired samples, independent samples t- and Pearson correlation tests were used for analysis. Forty-three patients with alcohol dependence who have been admitted for detoxification and thirty healthy controls were included in the study. The blood samples were drawn after the 1st day of admission and postdetoxification treatment in inpatients who reached to abstinence period and from 30 healthy controls. The Penn Alcohol Craving Scale and the Obsessive Compulsive Drinking Scale were applied to detect craving scores. Initial serum NUCB2/nesfatin-1 levels in patients were significantly lower than in the healthy control group (P < 0.001)....Continue Reading

References

May 2, 2001·Biological Psychiatry·F KieferK Wiedemann
Dec 2, 2005·Addiction Biology·Gerhard DammannFriedrich Martin Wurst
Oct 13, 2006·Nature·Shinsuke Oh-IMasatomo Mori

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