Serum of Behçet's disease enhances superoxide production of normal neutrophils

Free Radical Research
T YoshidaS Hirai

Abstract

Using an MCLA-dependent chemiluminescence technique, we evaluated superoxide production by neutrophils isolated from 7 patients with Behçet's disease. After stimulation by phorbol myristate acetate, N-formyl-methionyl-leucyl-phenylalanine or opsonized zymosan, neutrophils from the patients produced significantly more superoxide than those from 20 controls. Pretreatment of control neutrophils with serum prominently enhanced superoxide production, and serum from Behçet's disease patients had a significantly greater effect than that from controls. These findings suggest that serum from patients with Behçet disease contains the priming factor(s) that can enhance enhanced superoxide production by neutrophils in response to stimulation.

References

Jun 1, 1979·Annals of the Rheumatic Diseases·D W JamesM J Smith
Mar 1, 1977·Journal of Clinical Pathology·J D SobelD Merzbach
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R J FalkJ C Jennette
Feb 15, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·A NishidaT Goto
Jan 1, 1986·Journal of Free Radicals in Biology & Medicine·M YamadaY Mimura
Mar 1, 1973·The Journal of Clinical Investigation·B M BabiorJ T Curnutte
Apr 1, 1982·Infection and Immunity·S OhnoT Minagawa
Nov 1, 1982·Canadian Journal of Physiology and Pharmacology·J M McCord, R S Roy
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·I Fridovich
Aug 15, 1984·The Biochemical Journal·T F Slater
Aug 1, 1982·Annals of the Rheumatic Diseases·J N FordhamH L Currey
Jan 1, 1981·Archives of Dermatological Research·D DjawariJ Schötz

❮ Previous
Next ❯

Citations

Aug 11, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Keita FujimoriMasahiko Usui
Oct 9, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sadik SögütOmer Akyol
Oct 7, 2011·Pathology Research International·Umit Türsen
Nov 4, 2000·Expert Opinion on Investigational Drugs·T Sakane, M Takeno
Jun 22, 2005·Survey of Ophthalmology·Cem Evereklioglu
Jun 19, 2002·Neurological Research·Toshihiko YoshidaKoichi Okamoto
May 22, 2018·Current Rheumatology Reviews·Jibran Sualeh MuhammadKhalid Ahmed
Feb 27, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·B SancakM A Gürer
Oct 21, 2017·Arthritis Research & Therapy·Sandro Félix PerazzioLuis Eduardo Coelho Andrade
Apr 9, 2002·European Journal of Ophthalmology·C Evereklioglu, H Er
Sep 6, 2020·Scandinavian Journal of Immunology·Sandro F PerazzioMikko R J Seppänen
Nov 17, 2020·Frontiers in Immunology·Sandro F PerazzioAlexandre W S de Souza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.