Serum omentin-1 levels in type 2 diabetic obese women in relation to glycemic control, insulin resistance and metabolic parameters

Journal of Clinical & Translational Endocrinology
Nehal Hamdy ElsaidNagwa Abd El-Ghaffar Mohammed

Abstract

Omentin-1 a new anti-inflammatory adipokine has been identified as a major visceral (omental) secretory adipokine which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes. The aim of our study was to evaluate serum omentin-1 levels in type 2 diabetic obese females and assess its relation with glycemic control, insulin resistance and metabolic parameters. The study included 60 obese type 2 diabetic females and 30 healthy female subjects formed the control group. They subjected to full clinical examination, weight, height, waist and hip circumference. Fasting (blood glucose, insulin, lipid profile, omentin-1) and HbA1c were measured. BMI and HOMA-IR were calculated. Our data analyzed and expressed in terms of mean ± SD. Pearson correlation performed to study the correlation of serum omentin-1 in relation to glycemic control, insulin resistance and metabolic parameters in the studied groups. We found significant decrease in serum omentin-1 levels in cases with mean ± SD (16.5 ± 2.6 pg/ml) compared to controls (25.3 ± 1.0 pg/ml) (P < 0.001). We also found strong significant negative correlations between serum omentin-1 and (BMI, fasting insulin, HOMA-IR) (r = -0.909, -0.853, -0.511) resp...Continue Reading

Citations

Jun 15, 2019·Journal of Clinical Medicine·Katarzyna Komosinska-VassevKrystyna Olczyk
Apr 25, 2020·Journal of Clinical Medicine·Artur Borowski, Lucyna Siemińska
Jun 7, 2019·Cardiovascular Diabetology·Federico BiscettiAndrea Flex
Mar 12, 2020·Frontiers in Cardiovascular Medicine·Alan Chait, Laura J den Hartigh
May 23, 2020·Bioengineering & Translational Medicine·Amrita Banerjee, Jagdish Singh
Sep 3, 2020·International Journal of Molecular Sciences·Unai Galicia-GarciaCésar Martín
May 12, 2020·Current Cardiology Reviews·Lutfu AskinSerdar Turkmen

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