Serum osteopontin level and common carotid artery intima-media wall thickness in psoriasis

International Journal of Dermatology
Reza M RobatiP Toossi

Abstract

The association between psoriasis and cardiovascular disease is well documented, but the underlying mechanisms remain unknown. The relationship between osteopontin and psoriasis has been studied. High serum levels of osteopontin are reported in psoriasis, with increased cardiovascular risk factors in these patients. We evaluate the extent of subclinical atherosclerosis by measuring the mean intima-media wall thickness (MIMT) of the common carotid artery (CCA) in patients with psoriasis and assessing its correlation with osteopontin to identify vascular risk factors associated with psoriasis. Intima-media wall thickness of the CCA and plasma osteopontin were determined in 40 patients and 40 age- and sex-matched healthy control subjects. Median serum osteopontin was significantly higher in patients with psoriasis than in healthy control subjects. Mean intima-media wall thickness of the CCA was positively associated with plasma osteopontin level (r = 0.47, P < 0.0001), body mass index (r = 0.62, P < 0.0001), age (r = 0.54, P < 0.0001), total cholesterol (r = 0.54, P < 0.0001), and triglycerides (r = 0.65, P < 0.0001). This study shows higher levels of plasma osteopontin and MIMT-CCA in psoriasis patients than in healthy controls. ...Continue Reading

References

Oct 15, 1995·Circulation·K D O'BrienC M Otto
Apr 21, 1995·Annals of the New York Academy of Sciences·C M GiachelliM Almeida
Jul 6, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M CicconeG De Pergola
Dec 19, 2003·The New England Journal of Medicine·Mary J RomanJane E Salmon
Dec 21, 2005·Archives of Dermatology·Mark D HerronGerald G Krueger
Jan 20, 2006·European Heart Journal·Piercarlo MinorettiDiego Geroldi
May 19, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·Torsten Schäfer
Jun 17, 2006·Nature Reviews. Immunology·Göran K Hansson, Peter Libby
Oct 28, 2006·Seminars in Arthritis and Rheumatism·Oded KimhiOri Elkayam
Apr 17, 2007·Journal of the American Academy of Dermatology·Hilal Maradit KremersSherine E Gabriel
Nov 6, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·S El-MongyN El-Nour
Jul 26, 2013·Archives of Dermatological Research·D KadryL Rashed

❮ Previous
Next ❯

Citations

Jan 12, 2019·Indian Journal of Dermatology, Venereology and Leprology·Soheila NasiriShima Younespour
Feb 16, 2019·European Journal of Clinical Investigation·Federico CarboneBarbara M Colombo
Mar 7, 2021·Journal of Clinical Medicine·Joanna BartosińskaGrażyna Chodorowska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.