Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension.

Pulmonary Circulation
Robin CondliffeAllan Lawrie

Abstract

We previously reported that osteoprotegerin (OPG) is regulated by pathways associated with pulmonary arterial hypertension (PAH), and is present at elevated levels within pulmonary vascular lesions and sera from patients with idiopathic PAH (IPAH). Since OPG is a naturally secreted protein, we investigated the relationship between serum OPG and disease severity and outcome in patients with IPAH and animal models. OPG mRNA expression was measured in pulmonary artery smooth muscle cells (PASMC) from pulmonary arteries of patients with and without IPAH. Serum concentrations of OPG were measured in a retrospective and prospective group of patients. OPG levels were compared with phenotypic data and other putative PAH biomarkers. Prognostic significance was assessed and levels compared with healthy controls. Correlation of OPG and pulmonary vascular remodeling was also performed in rodent models of PAH. OPG mRNA was significantly increased 2-fold in PASMC isolated from explanted PAH lungs compared with control. Serum OPG concentrations were markedly elevated in IPAH compared with controls. In Cohort 1 OPG levels significantly correlated with mean right atrial pressure and cardiac index, while in Cohort 2 significant correlations exis...Continue Reading

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Citations

Dec 12, 2012·American Journal of Respiratory and Critical Care Medicine·Christopher J RhodesMartin R Wilkins
Mar 25, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Neeraj DhaunDavid J Webb
Oct 25, 2014·Biomarkers in Medicine·Neil McGlinchey, Martin K Johnson
May 23, 2014·Clinical Biochemistry·C Pérez de CirizaN Varo
Sep 8, 2016·Epigenomics·Alexander Mk RothmanAllan Lawrie
Jul 8, 2016·Biomarker Insights·Vanessa Rameh, Antoine Kossaify
Jun 22, 2014·Circulation Research·Marlene RabinovitchMark R Nicolls
Nov 3, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Lin-Hua DengWei Liu

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Methods Mentioned

BETA
PCR
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
GraphPad Prism

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