Serum osteoprotegerin levels and long-term prognosis in patients with stable angina pectoris

Atherosclerosis
Eva Ringdal PedersenOttar Nygård

Abstract

Osteoprotegerin (OPG) is a member of the tumor necrosis factor superfamily with pleiotropic effects on bone metabolism, endocrine function and the immune system. Circulating OPG levels are elevated in cardiovascular disease (CVD). We assessed serum OPG as predictor of long-term prognosis in patients with suspected stable angina pectoris (SAP) undergoing elective coronary angiography. Samples were obtained from 1025 patients (median [25th, 75th percentile] age 62 [54, 70] years, 71.9% men). At inclusion, 43.2% of patients had single or double vessel disease, whereas 34.3% had triple vessel disease. During a median follow-up of 73 months, 11.0% of patients died, 5.9% died from CVD and 10.0% experienced an acute myocardial infarction (MI). In univariable analyses, strong associations were observed between OPG concentrations and all-cause mortality, CVD mortality and the incidence of MI (fatal or nonfatal). However, adjustment for conventional risk factors attenuated the risk estimates which were no longer significant, except for the subgroup with levels above the 90th percentile. For decile 10 versus deciles 1-9 of serum OPG, the following multivariable hazard ratios (95% confidence intervals) were observed: All-cause mortality: 1...Continue Reading

References

Jan 1, 1992·Breast Cancer Research and Treatment·T HastieR Tibshirani
Jun 6, 2003·Cytokine & Growth Factor Reviews·Matthew C Walsh, Yongwon Choi
May 15, 2004·Stroke; a Journal of Cerebral Circulation·Jonathan GolledgeMirko Karan
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Eloy SchulzVicente Gilsanz
Nov 16, 2004·Journal of the American College of Cardiology·Thor UelandPål Aukrust
Feb 25, 2005·The Journal of Clinical Endocrinology and Metabolism·Birgit A MosheimerChristian J Wiedermann
Jan 20, 2006·European Heart Journal·Piercarlo MinorettiDiego Geroldi
Jun 7, 2007·The Journal of Clinical Endocrinology and Metabolism·F JosephW D Fraser
Feb 12, 2008·Journal of the American College of Cardiology·Torbjørn OmlandKenneth Caidahl
Nov 15, 2008·Atherosclerosis·Ann Van Campenhout, Jonathan Golledge
May 8, 2010·Journal of the American College of Cardiology·Shreenidhi M VenurajuAvijit Lahiri

❮ Previous
Next ❯

Citations

Jun 12, 2013·Cardiology·L XiY Chen
Jul 10, 2012·Journal of Cardiovascular Medicine·Marco M CicconeMario E Lepera
Feb 13, 2013·International Journal of Endocrinology·Areti AugouleaGeorge Creatsas
Oct 11, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Unni SyversenErik Fink Eriksen
Jun 14, 2014·Clinical Endocrinology·Christian TrolleClaus Højbjerg Gravholt
Nov 1, 2012·Annals of Medicine·Martina MontagnanaGian Cesare Guidi
Jan 25, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Susanne E HosbondHans Mickley
Jul 16, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Mette BjerreUNKNOWN Claricor Trial Group
Jul 6, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pawel SzulcLorenz C Hofbauer
Nov 22, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Fu-Qiang LiuJian-Jun Mu
Jan 14, 2018·European Journal of Clinical Investigation·Gerasimos SiasosDimitris Tousoulis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.