Abstract
Osteoprotegerin (OPG) is a member of the tumor necrosis factor superfamily with pleiotropic effects on bone metabolism, endocrine function and the immune system. Circulating OPG levels are elevated in cardiovascular disease (CVD). We assessed serum OPG as predictor of long-term prognosis in patients with suspected stable angina pectoris (SAP) undergoing elective coronary angiography. Samples were obtained from 1025 patients (median [25th, 75th percentile] age 62 [54, 70] years, 71.9% men). At inclusion, 43.2% of patients had single or double vessel disease, whereas 34.3% had triple vessel disease. During a median follow-up of 73 months, 11.0% of patients died, 5.9% died from CVD and 10.0% experienced an acute myocardial infarction (MI). In univariable analyses, strong associations were observed between OPG concentrations and all-cause mortality, CVD mortality and the incidence of MI (fatal or nonfatal). However, adjustment for conventional risk factors attenuated the risk estimates which were no longer significant, except for the subgroup with levels above the 90th percentile. For decile 10 versus deciles 1-9 of serum OPG, the following multivariable hazard ratios (95% confidence intervals) were observed: All-cause mortality: 1...Continue Reading
References
Jan 1, 1992·Breast Cancer Research and Treatment·T HastieR Tibshirani
Aug 24, 1999·American Journal of Epidemiology·R ClarkeR Peto
Sep 7, 2000·European Heart Journal
Oct 31, 2001·Calcified Tissue International·D P KielP W Wilson
Nov 27, 2001·European Journal of Endocrinology·T UelandP Aukrust
Sep 5, 2002·Circulation·Shuichi JonoYoshiki Nishizawa
Jun 6, 2003·Cytokine & Growth Factor Reviews·Matthew C Walsh, Yongwon Choi
May 15, 2004·Stroke; a Journal of Cerebral Circulation·Jonathan GolledgeMirko Karan
Sep 10, 2004·The Journal of Clinical Endocrinology and Metabolism·Eloy SchulzVicente Gilsanz
Nov 16, 2004·Journal of the American College of Cardiology·Thor UelandPål Aukrust
Nov 27, 2004·Circulation Research·Patricia Collin-Osdoby
Feb 25, 2005·The Journal of Clinical Endocrinology and Metabolism·Birgit A MosheimerChristian J Wiedermann
May 11, 2005·Circulation·Thor UelandPål Aukrust
Aug 24, 2005·Atherosclerosis·Sophie ZieglerErich Minar
Jan 20, 2006·European Heart Journal·Piercarlo MinorettiDiego Geroldi
Jun 7, 2007·The Journal of Clinical Endocrinology and Metabolism·F JosephW D Fraser
Jun 15, 2007·Statistics in Medicine·Michael J PencinaRamachandran S Vasan
Sep 14, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·H P SennelsS Sørensen
Feb 12, 2008·Journal of the American College of Cardiology·Torbjørn OmlandKenneth Caidahl
Nov 15, 2008·Atherosclerosis·Ann Van Campenhout, Jonathan Golledge
Dec 2, 2008·Clinical Chemistry·Mads NyboLars Melholt Rasmussen
May 8, 2010·Journal of the American College of Cardiology·Shreenidhi M VenurajuAvijit Lahiri
Citations
Jun 12, 2013·Cardiology·L XiY Chen
Jul 10, 2012·Journal of Cardiovascular Medicine·Marco M CicconeMario E Lepera
Feb 13, 2013·International Journal of Endocrinology·Areti AugouleaGeorge Creatsas
Oct 11, 2011·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Unni SyversenErik Fink Eriksen
Jun 17, 2011·Clinical Cardiology·Qingmiao YangYong Huo
Jun 14, 2014·Clinical Endocrinology·Christian TrolleClaus Højbjerg Gravholt
Nov 1, 2012·Annals of Medicine·Martina MontagnanaGian Cesare Guidi
Jan 25, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Susanne E HosbondHans Mickley
Jul 16, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Mette BjerreUNKNOWN Claricor Trial Group
Mar 17, 2015·Atherosclerosis·Eirik Wilberg RebnordOttar Nygård
Jun 19, 2012·International Journal of Cardiology·Georg FuernauHolger Thiele
Aug 12, 2014·Atherosclerosis·Susanne Elisabeth HosbondHans Mickley
May 31, 2016·Scientifica·Umberto BarberoFiorenzo Gaita
Mar 24, 2016·PloS One·Heidi BorgeraasJøran Hjelmesæth
Jul 6, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pawel SzulcLorenz C Hofbauer
Jun 4, 2019·Biomarkers in Medicine·Jeng-Feng LinYu-Lin Ko
Feb 28, 2016·Lipids in Health and Disease·Heidi BorgeraasJøran Hjelmesæth
Nov 22, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Fu-Qiang LiuJian-Jun Mu
Jul 21, 2017·Frontiers in Endocrinology·Meenal Mavinkurve, Clodagh S O'Gorman
Oct 30, 2018·Journal of the American Heart Association·Lena TschidererPeter Willeit
Jan 14, 2018·European Journal of Clinical Investigation·Gerasimos SiasosDimitris Tousoulis
Jan 31, 2019·Angiology·Marinos KosmopoulosGerasimos Siasos
Apr 15, 2020·Atherosclerosis·Mette BjerreChristian Gluud