Serum oxytocinase activity is related to tumor growth parameters in N-methyl nitrosourea induced rat breast cancer

Life Sciences
María del Pilar CarreraJ M Martínez-Martos

Abstract

Oxytocinase has been reported to hydrolyse the peptide hormone oxytocin (OT). We have previously described changes in oxytocinase activity in human breast cancer, where a highly significant increase occurred in tumoral tissue. In the present work, we analysed oxytocinase activity in serum of rats with breast cancer induced by N-methyl-nitrosourea (NMU). We also correlated these data with the number and size of tumors and the body weight of the animals to evaluate the putative value of this activity as a biological marker of the disease. Our results confirm the involvement of OT in carcinogenesis and suggest a mayor role for oxytocinase activity in the development of breast cancer.

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Citations

Jan 6, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·María Pilar Carrera-GonzálezJose Manuel Martínez-Martos
Aug 19, 2007·Regulatory Peptides·Gorka LarrinagaAdolfo Varona
May 28, 2019·Biological Research for Nursing·José Manuel Martínez-MartosMaría Encarnación Aguilar-Ferrandiz
Nov 20, 2016·Scientific Reports·Joelle MakoukjiArafat Tfayli
Nov 8, 2020·Cancers·María Jesús Ramírez-ExpósitoJose Manuel Martínez-Martos
Dec 17, 2020·Nursing Research·María Encarnación Aguilar-FerrándizMaría Correa-Rodríguez
Feb 26, 2021·Nursing Research·María Encarnación Aguilar-FerrándizMaría Correa-Rodríguez

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Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
María del Pilar CarreraJ M Martínez-Martos
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
María del Pilar CarreraJ M Martínez-Martos
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