Serum P-selectin, soluble vascular cell adhesion molecule-I (s-VCAM-I) and soluble intercellular adhesion molecule-I (s-ICAM-I) levels in bladder carcinoma patients with different stages

International Immunopharmacology
Ugur CoskunSinan Sozen

Abstract

Adhesion molecules are thought to have a role in the host defense against carcinogenesis. In this study, we measured serum platelet-(P-) selectin, soluble vascular cell adhesion molecule-I (s-VCAM-I), and soluble intercellular adhesion molecule-I (s-ICAM-I) levels in 51 sequential bladder cancer patients at our urology clinic and 8 controls. Serum levels of P-selectin, s-VCAM-I and s-ICAM-I were significantly higher in all patients than controls. Serum P-selectin and s-ICAM-I levels did not differ based on tumor (T) stage and tumor grade, whereas serum levels of s-VCAM-I were significantly higher in patients with muscle invasive tumors than those with superficial tumors. Further, s-VCAM-I levels correlated with T stage. In conclusion, significantly increased P-selectin, s-VCAM-I, and s-ICAM-I levels were observed in patients with bladder cancer, and s-VCAM-I levels correlated with T stage. Thus, we suggest that the analysis of serum s-VCAM-I levels may provide a prognostic test for T stage and bladder cancer progression during and/or following therapy.

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Citations

May 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shian-Shiang WangShun-Fa Yang
Nov 17, 2009·Cancer Investigation·Nektaria MakriliaKostas Syrigos
Feb 18, 2016·Journal of Thyroid Research·Toral P KobawalaNandita R Ghosh
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Apr 3, 2020·Molecular Cancer Research : MCR·Axel JohnChristian Gorzelanny

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