Abstract
The functional significance of alterations in expression of tumour-suppressor gene p53 and 70-kDa heat-shock protein (HSP70) in eliciting p53-specific humoral response in oral-cancer patients is not yet known. In this study, p53 auto-antibodies were analyzed in sera from oral-cancer patients by immunoblotting and results were correlated with clinicopathological features of the patients as well as with the levels of HSP70, p53 and p53-HSP70 complexes in matched patients' tumour tissue, for determining their diagnostic/prognostic significance and relationship to survival. Circulating anti-p53 antibodies were observed in 7 of 30 cancer patients and 3 of 25 patients with pre-malignant lesions. Over-expression of p53 protein in matched oral lesions was observed in 22 of these 30 cancer patients and 14 of 25 patients with dysplastic lesions. No detectable levels of p53 protein or anti-p53 antibodies were observed in normal subjects (15 cases). Elevated levels of HSP70 were observed in 23 of these 30 oral tumours and 17 of 25 dysplastic lesions. All the anti-p53-antibody-seropositive cases showed elevated levels of p53 and HSP70 proteins, as well as formation of p53-HSP70 complexes, in matched dysplastic or malignant lesions, suggesti...Continue Reading
References
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A M DavidoffJ R Marks
Sep 1, 1985·Experimental Cell Research·C Caron de FromentelR Cassingena
Oct 15, 1982·International Journal of Cancer. Journal International Du Cancer·L V CrawfordR D Bulbrook
Jul 1, 1995·Nature Medicine·R LubinT Soussi
Sep 1, 1995·British Journal of Cancer·J G HoubiersC J Melief
Mar 1, 1995·Gut·P Laurent-PuigT Soussi
Nov 30, 1994·Experientia·P K Srivastava
Aug 1, 1994·International Journal of Cancer. Journal International Du Cancer·J KaurR Ralhan
Jun 1, 1993·British Journal of Cancer·J E BurnsE K Parkinson
May 3, 1996·International Journal of Cancer. Journal International Du Cancer·A K MunirajanN Tsuchida
Jan 1, 1996·European Journal of Cancer. Part B, Oral Oncology·J KaurR Ralhan
May 1, 1996·European Journal of Cancer. Part B, Oral Oncology·H Raybaud-DiogèneR A Monteil
Sep 4, 1996·Journal of the National Cancer Institute·J BourhisT Soussi
Dec 11, 1995·International Journal of Cancer. Journal International Du Cancer·J Kaur, R Ralhan
Citations
Mar 4, 2008·Journal of Proteome Research·Karen S AndersonJoshua LaBaer
Jun 30, 2009·Cancer Immunology, Immunotherapy : CII·Miriam ReuschenbachNicolas Wentzensen
Aug 28, 2003·Cancer·Thierry LebretHenry Botto
Apr 29, 2006·International Journal of Cancer. Journal International Du Cancer·Narayanan K NarayananDominick Nargi
Dec 1, 2007·Proteomics. Clinical Applications·Sanjeev ShuklaSurekha M Zingde
Jan 22, 2013·European Journal of Oral Sciences·Geo FrancisS Kannan
Jan 28, 2003·Cancer·Hideaki ShimadaUNKNOWN Japan p53 Antibody Research Group
Apr 10, 2015·Oral and Maxillofacial Surgery·Azadeh Andisheh-Tadbir, Mehrnaz Fakharian
Aug 22, 2000·The Journal of Pathology·S WarnakulasuriyaM Tavassoli
Jan 4, 2013·PloS One·Jun ZhangKe Li
Oct 3, 2006·The American Journal of Dermatopathology·Juan M SeoaneJosé Manuel Aguirre
Jul 29, 2008·Odontology·Yutaka YamazakiYoshimasa Kitagawa
Feb 23, 1999·British Journal of Cancer·R SaffroyA Lemoine
Feb 15, 2020·Sensors·Yen-Heng LinKai-Ping Chang
Apr 20, 2020·Oral Diseases·Antonio CelentanoCamile S Farah
Feb 4, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Zhi-Cheng YangJun Zhang
Feb 3, 2006·Cancer Research·Al ErkanliRichard B S Roden
Dec 7, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marion E CouchDavid Sidransky
Dec 12, 2001·Critical Reviews in Oncology/hematology·T Minamoto, Z Ronai
Jun 23, 1999·Cancer Letters·M H TsujiH Yoshida