Serum paraoxonase and arylesterase activities in Iranian patients with nonalcoholic fatty liver disease

Pathophysiology : the Official Journal of the International Society for Pathophysiology
Mohammad HashemiSaeid Ghavami

Abstract

The aim of the study was to investigate paraoxonase-1 (PON1) and aryl esterase (ARE) activities in patients with nonalcoholic fatty liver disease (NAFLD). This case-control study was done on 83 subjects with confirmed NAFLD (50 male, 33 female, age; 40.46±12.13 years) and 138 healthy individuals (75 male, 63 female; age; 40.94±14.50 years). PON1, salt-stimulated PON1 and ARE activities were determined using paraoxon and phenyl acetate as substrate, respectively. The levels of PON1 activities in NAFLD and healthy individuals were 90.83±63.65 IU/L and 79.41±68.14 IU/L, respectively. There was no significant differences regarding PON1 activity between NAFLD and healthy subjects (p=0.229). While, ARE activity was significantly higher in NAFLD (83.34±28.36 KU/L) than in normal subjects (64.06±27.49 KU/L) (p<0.001). Our results showed that PON1 activity is not a promising biomarker for the evaluation of NAFLD while arylesterase may have, but further studies in larger samples with different ethnic groups are required to validate our findings.

References

Aug 1, 1995·Biulleten' eksperimental'noĭ biologii i meditsiny·A A VishnevskiĭL S Kostiuchenko
Jan 1, 1993·Nature Genetics·R HumbertC E Furlong
Nov 1, 1996·Nature Medicine·B N La Du
Apr 18, 1998·Gastroenterology·C P Day, O F James
Apr 20, 2000·The Journal of Clinical Investigation·I A LeclercqG R Robertson
Apr 12, 2001·Seminars in Liver Disease·S Chitturi, G C Farrell
Dec 26, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anna Mae Diehl
Apr 16, 2004·Seminars in Liver Disease·Elizabeth M Brunt
Jul 16, 2004·The Journal of Clinical Investigation·Jeffrey D Browning, Jay D Horton
Sep 30, 2004·Free Radical Biology & Medicine·Michael Aviram, Mira Rosenblat
Jul 5, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Natàlia FerréJorge Joven
Jan 30, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mungli PrakashPanambur V Bhandary
Mar 6, 2007·Clinical Biochemistry·Judit MarsillachJordi Camps
Sep 25, 2007·International Journal of Clinical Practice·M AslanO Erel
Dec 10, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Raj Vuppalanchi, Naga Chalasani
Mar 4, 2010·Genetics and Molecular Research : GMR·M HashemiS Ghavami
Mar 27, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Vivekananda KedageMungli Prakash
Sep 3, 2010·Genetics and Molecular Research : GMR·M HashemiS Ghavami
Nov 10, 2010·European Journal of Endocrinology·Mohammad HashemiAdam Torkmanzehi
Dec 7, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Mohamamd NaderiMohammadamin Momenimoghaddam
Mar 25, 2011·Clinics and Research in Hepatology and Gastroenterology·Dor Mohammad Kordi-TamandaniAdam Torkamanzehi
Dec 18, 2015·Journal of Clinical and Diagnostic Research : JCDR·Anand K PyatiVinod Wali

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Citations

Apr 3, 2014·Nephro-urology Monthly·Mohammad HashemiAbdolkarim Moazeni-Roodi
Apr 30, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Askın Tas HekimogluIlker Kelle
May 16, 2019·Annals of Clinical Biochemistry·Jelena JanacVesna Spasojević-Kalimanovska
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kazuhiko KotaniAlejandro Gugliucci

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