Serum pepsinogens and risk of gastric and oesophageal cancers in the General Population Nutrition Intervention Trial cohort.

Gut
J-S RenChristian C Abnet

Abstract

Low serum pepsinogen I (PGI) and low pepsinogen I/pepsinogen II ratio (PGI/II ratio) are markers of gastric fundic atrophy. We aimed to prospectively test the association between serum PGI/II ratio and risks of gastric non-cardia adenocarcinoma, gastric cardia adenocarcinoma, and oesophageal squamous cell carcinoma (OSCC). Case-cohort study nested in a prospective cohort with over 15 years of follow-up. Rural region of the People's Republic of China. Men and women aged 40-69 years at study baseline. Adjusted hazard ratios and 95% confidence intervals for the association between serum PGI/II ratio and cancer risk. Compared to subjects with PGI/II ratio of >4, those with <or=4 had hazard ratios (HRs) (95% CIs) of 2.72 (1.77 to 4.20) and 2.12 (1.42 to 3.16) for non-cardia and cardia gastric adenocarcinomas, respectively. Risk of both cancers was also increased when we used other cut points ranging from 3 to 6, or quartile models, or nonlinear continuous models. Risk of OSCC was marginally increased in those with PGI/II ratio <or=4, with HR (95% CI) of 1.56 (0.99 to 2.47), but quartile models and continuous models showed no increased risk. The nonlinear continuous models suggested that any single cut point collapsed subjects with d...Continue Reading

References

Mar 16, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·G N StemmermannL K Heilbrun
Jan 1, 1995·Japanese Journal of Cancer Research : Gann·H FukudaM Katoh
Jul 1, 1993·Journal of Clinical Gastroenterology·S RakićM Milićević
Aug 13, 2002·Gut·S M DawseyP J Limburg
Jan 22, 2004·International Journal of Cancer. Journal International Du Cancer·Hiroshi OhataMasao Ichinose
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Gina D TranPhilip R Taylor
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Akiko ShiotaniDavid Y Graham
May 18, 2005·The Journal of Infectious Diseases·Abraham M Y NomuraMartin J Blaser
Jan 31, 2006·American Journal of Epidemiology·Yoshinori OishiMitsuo Iida
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Melanie Nicole Weck, Hermann Brenner
Dec 21, 2006·British Journal of Cancer·F KamangarS M Dawsey
May 10, 2007·The American Journal of Gastroenterology·Katsunori IijimaTooru Shimosegawa
Aug 8, 2007·Gastroenterology·Pelayo Correa, Jeanmarie Houghton
Mar 18, 2008·Japanese Journal of Clinical Oncology·Chisato HamashimaTomotaka Sobue
May 20, 2008·International Journal of Cancer. Journal International Du Cancer·Melanie N Weck, Hermann Brenner

❮ Previous
Next ❯

Citations

Apr 30, 2010·Digestive Diseases and Sciences·Pelayo Correa
Jul 9, 2010·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chen-Shuan ChungHsiu-Po Wang
Jun 23, 2011·Journal of the National Cancer Institute·Gwen MurphyNeal D Freedman
Sep 10, 2010·Current Opinion in Gastroenterology·Peter Malfertheiner, Michael Selgrad
Jul 22, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Michael B CookFarin Kamangar
Sep 19, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wanyan Deng, Jianping Xie
Feb 1, 2012·BMC Gastroenterology·Jan BornscheinPeter Malfertheiner
Apr 13, 2011·World Journal of Gastroenterology : WJG·Yan-Cheng DaiYa-Li Zhang
Jan 18, 2013·World Journal of Gastroenterology : WJG·Xue-Yuan CaoJing Jiang
Apr 20, 2013·World Journal of Gastroenterology : WJG·Emiliano de Carvalho AlmodovaErika Veruska Paiva Ortolan
May 8, 2014·World Journal of Gastroenterology : WJG·Xin NiuYou-Lin Qiao
Oct 29, 2010·Gut and Liver·Nayoung Kim, Hyun Chae Jung
Aug 4, 2011·European Journal of Gastroenterology & Hepatology·Marino VeneritoPeter Malfertheiner
Nov 26, 2010·International Journal of Cancer. Journal International Du Cancer·Shih-Wen LinChristian C Abnet
Mar 13, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S L ZhouL D Wang
Mar 28, 2013·Gastroenterology Research and Practice·Hyung-Keun KimYoung-Seok Cho
Apr 9, 2015·Journal of Cancer Prevention·Yo Han Park, Nayoung Kim
Nov 8, 2011·The American Journal of Gastroenterology·Michael Blaise Cook
Feb 20, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Minkyo SongCharles S Rabkin
Mar 30, 2019·Thoracic Cancer·Shao-Ming WangYou-Lin Qiao
Jul 28, 2019·International Journal of Cancer. Journal International Du Cancer·Natalie R PritchettGwen Murphy
Dec 1, 2017·European Journal of Gastroenterology & Hepatology·Andrew T KunzmannHelen G Coleman
Apr 11, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kenshi YaoHisao Tajiri
Sep 13, 2013·The American Journal of Clinical Nutrition·Tram Kim LamChristian C Abnet
Sep 11, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shao-Ming WangChristian C Abnet
Mar 13, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Parisa KarimiFarin Kamangar
Apr 5, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Guoqin YuChristian C Abnet
Jan 3, 2020·Gut and Liver·Juntaro MatsuzakiHidekazu Suzuki
May 1, 2021·Journal of Gastroenterology and Hepatology·Yongjia LiuXingxiang He
May 24, 2021·BMC Cancer·Yingxi ChenChristian C Abnet
Jun 29, 2021·International Journal of Cancer. Journal International Du Cancer·Jianhua GuWenqiang Wei
Jul 9, 2021·Digestive Diseases and Sciences·Ali SoroushJulian A Abrams
Sep 10, 2021·International Journal of Cancer. Journal International Du Cancer·Peipei GaoXingdong Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Related Papers

International Journal of Cancer. Journal International Du Cancer
Farin KamangarSanford M Dawsey
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Arghavan Haj-SheykholeslamiSadegh Massarrat
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
David Y GrahamVictor Cardenas
International Journal of Cancer. Journal International Du Cancer
Hermann BrennerMelanie Nicole Weck
© 2021 Meta ULC. All rights reserved