PMID: 3678064Nov 1, 1987

Serum phenobarbital concentration predictions by a personal computer software system

Drug Intelligence & Clinical Pharmacy
J W GingeryJ A Jernigan

Abstract

The ability of a personal computer software system to predict actual serum phenobarbital concentrations (SPC) in outpatients taking phenobarbital chronically was assessed by comparing actual with predicted SPC for accuracy, bias, and precision. Data for a four-year period were collected on patients at an outpatient clinic's pharmacokinetic consultation service. The study group included 50 adults and children with at least one SPC taken at a known time after dose administration. Input variables were weight, sex, height, age, concomitant drugs and diseases, phenobarbital dosage regimen, and the time and reported value of all SPC. Initially, SIMKIN (SIMulated KINetics) simulated dosing regimens on the basis of literature estimates of pharmacokinetic parameters; SPC were then estimated for these regimens and compared with actual values. One or two additional SPC were added to the input data and analyzed, and the predicted SPC compared with actual values. Although SIMKIN's accuracy and bias as measured by regression analysis and mean prediction error, respectively, were within clinically acceptable limits, the precision was not. However, these results are limited by the population studied. Patient compliance, concomitant phenytoin t...Continue Reading

References

Sep 30, 1978·Lancet·E H Reynolds
Feb 1, 1979·Annals of Internal Medicine·J K Penry, M E Newmark
May 1, 1979·Journal of Clinical Pharmacology·C T ViswanathanP G Welling
Nov 1, 1979·Neurology·L A LockmanN Virnig
Dec 2, 1977·European Journal of Clinical Pharmacology·G Heimann, E Gladtke
Mar 1, 1978·Acta paediatrica Scandinavica·L O BoréusN Kållberg
Jan 1, 1976·Clinical Pharmacokinetics·E F Hvidberg, M Dam
Mar 1, 1975·Computer Programs in Biomedicine·G A Iben, J H Anderson
Nov 1, 1974·Archives of Neurology·H Kutt, J K Penry
Sep 1, 1974·The Medical Clinics of North America·A J Atkinson
Jun 1, 1974·Clinical Pharmacology and Therapeutics·F VajdaA Breckenridge
Dec 1, 1968·Archives of Neurology·F BuchthalH Simonsen
Jul 6, 1971·Annals of the New York Academy of Sciences·P L MorselliS Garattini
Apr 1, 1980·Clinical Pharmacology and Therapeutics·I H PatelR E Cutler
Jun 1, 1981·Biochemical Pharmacology·I M Kapetanović, H J Kupferberg
Mar 1, 1982·Archives of Disease in Childhood·N W SvenningsenH Ahlström
Jan 1, 1982·European Journal of Clinical Pharmacology·A J WilenskyS P Kaluzny
Aug 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·L B Sheiner, S L Beal
Aug 1, 1980·The Journal of Pediatrics·P D WalsonD Perrier

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