Serum phosphate is related to adiposity in healthy adults

European Journal of Clinical Investigation
Emma O BillingtonIan R Reid

Abstract

Inorganic phosphate is a crucial component of cellular energy metabolism. We have identified an inverse relationship between serum phosphate concentration and fat mass in a cohort of healthy men. This study reports those data and determines whether this association is present in two female populations. Cross-sectional data from three independent cohorts, consisting of healthy adult males (Male Cohort, n = 323) and healthy postmenopausal women (Female Cohort 1, n = 185; and Female Cohort 2, n = 1471), are reported. Associations between serum phosphate and weight, body mass index (BMI), fat mass and bone mineral density (BMD) were assessed. In a fourth cohort of postmenopausal women (FGF23 Cohort, n = 20), associations between fibroblast growth factor 23 (FGF23), weight and BMI were assessed. Serum phosphate correlated inversely with weight, BMI and fat mass across all three cohorts (r = -0·13 to -0·31, P < 0·0001-0·02). Associations were diminished after adjustment for PTH, but remained significant. In the FGF23 Cohort, FGF23 was positively correlated with weight (r = 0·60, P = 0·007) and BMI (r = 0·49, P = 0·03). Phosphate was inversely associated with BMD in Female Cohorts 1 and 2 (r = -0·08 to -0·29, P < 0·0001-0·02). This re...Continue Reading

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Citations

Apr 4, 2019·Clinical Endocrinology·Emma O BillingtonIan R Reid
Mar 4, 2020·Nutrients·Héctor Vázquez-LorenteElena Planells
Nov 28, 2019·The Journal of Clinical Endocrinology and Metabolism·Nasser A DhayatDaniel G Fuster
Sep 6, 2018·Endocrine Reviews·Ian R ReidJillian Cornish
Nov 30, 2018·Journal of Clinical Biochemistry and Nutrition·Yukiko ImiYutaka Taketani

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