Serum phosphate levels reflect responses to cardiac resynchronization therapy in chronic heart failure patients

Journal of Arrhythmia
Yoshiyuki KamiyamaYasuchika Takeishi

Abstract

Recent studies have shown that high levels of serum phosphate are associated with adverse cardiovascular events. However, little is known about the relation between phosphate levels and improvement of cardiac function in chronic heart failure (CHF) patients who underwent cardiac resynchronization therapy (CRT). The purpose of this study was to examine whether serum phosphate levels were able to predict responders to CRT and adverse cardiac events. The study population consisted of 30 CHF patients (24 males, mean age 65.7±8.5 years) who received CRT with defibrillator (CRT-D) implantation. Levels of serum phosphate were measured before, and 6 months after, CRT-D implantation. Left ventricular end-diastolic volume and end-systolic volume were assessed simultaneously by echocardiography. In addition, the rate of re-hospitalization due to worsening of heart failure was investigated. All patients were divided into 2 groups: responders (Group-R, n=18) and non-responders (Group-NR, n=12) to CRT-D. Responders were defined as patients who showed >15% reduction in left ventricular end-systolic volume. We compared these parameters between the 2 groups. Serum phosphate levels were significantly lower in Group-R than in Group-NR (3.3±0.2 vs...Continue Reading

References

Dec 24, 2004·Journal of the American Society of Nephrology : JASN·Bryan KestenbaumDennis L Andress
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Oct 26, 2005·Circulation·Marcello TonelliUNKNOWN Cholesterol And Recurrent Events Trial Investigators
Jan 29, 2011·Journal of the American College of Cardiology·Rutger J Van BommelJeroen J Bax
Mar 19, 2011·European Journal of Heart Failure·Louise Lind SchierbeckJens-Erik Beck Jensen
May 4, 2012·European Journal of Heart Failure·John G F ClelandJean-Claude Daubert
Jan 1, 2013·Journal of Cardiac Failure·Michael EssGerhard Poelzl

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Citations

Apr 23, 2017·Heart Failure Reviews·E C ChristopoulouG Liamis

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