PMID: 9449444Feb 4, 1998Paper

Serum phospholipase A2, amylase, lipase, and urinary amylase activities in relation to the severity of acute pancreatitis

The European Journal of Surgery = Acta Chirurgica
A MäkeläT Schröder

Abstract

To compare serum phospholipase A2 activity with measurements of conventional enzymes as an indicator of the severity of acute pancreatitis. Prospective study. University hospital, Finland. 80 Consecutive patients with acute pancreatitis. Serum and urine samples were taken daily for a week after admission. Serum phospholipase A2, amylase, lipase, and urinary amylase activities. On admission, the serum amylase and lipase activities increased in parallel in all patients. However, the mean serum phospholipase A2 activity was three times higher in the patients with acute fulminant pancreatitis than in those with milder disease. The phospholipase A2 activity remained high during the course of the severe disease, whereas the other enzyme activities decreased appreciably during the first week. In contrast to the other enzyme activities that of serum phospholipase A2 correlated well with the severity of the acute pancreatitis. Heating at 60 degrees C for 45 minutes to inactivate the non-pancreatic thermolabile phospholipase A2 reduced the total serum phospholipase A2 activity more than the enzyme activity in the homogenates of pancreatic tissue, which suggests that extrapancreatic phospholipase A2 is present in serum. The receiver opera...Continue Reading

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