Serum plant sterols and lathosterol related to cholesterol absorption in coeliac disease

Clinica Chimica Acta; International Journal of Clinical Chemistry
M VuoristoT A Miettinen

Abstract

The concentrations of the plant sterols, campesterol and beta-sitosterol in serum, normally correlate with the efficiency of cholesterol absorption, whereas the concentration of lathosterol, a cholesterol precursor sterol, closely parallels changes in cholesterol synthesis. In this study we explored whether the plant sterol concentrations in serum in coeliac disease are determined by cholesterol absorption and whether they alone or with the serum lathosterol concentration, could be used for screening the activity of coeliac disease. In six patients the plant sterol concentrations in serum were significantly lower than in 17 control subjects, the reduction being more marked for campesterol than for beta-sitosterol: the serum lathosterol concentration was significantly higher than in the control subjects. The opposite changes in serum plant sterols and lathosterol were recorded in patients on a gluten-free diet. The plant sterol concentrations in serum (nmol/mg of cholesterol) were positively correlated with each other, and with the percentage absorption of cholesterol and with xylose absorption; they were negatively correlated with faecal fat, but not with faecal plant sterols. Thus, the low plant sterol concentrations in serum ...Continue Reading

References

Sep 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·T A Miettinen, S Tarpila
Jan 1, 1986·The American Journal of Clinical Nutrition·R S Tilvis, T A Miettinen
Jan 1, 1985·Gastroenterology·M Vuoristo, T A Miettinen
Apr 1, 1974·The Journal of Clinical Investigation·A K Bhattacharyya, W E Connor
Jan 1, 1971·Scandinavian Journal of Gastroenterology·T A Miettinen, M Siurala
May 1, 1970·The Journal of Clinical Investigation·G SalenS M Grundy
Jan 1, 1970·World Review of Nutrition and Dietetics·M Pekkarinen
Jan 1, 1971·Zeitschrift Für Klinische Chemie Und Klinische Biochemie·T A Miettinen, M Siurala
Aug 1, 1969·Metabolism: Clinical and Experimental·R G GouldC B Taylor
Jan 1, 1983·Annual Review of Nutrition·S M Grundy
Sep 15, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·T A Miettinen

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Citations

Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·W H SutherlandE R Nye
Nov 1, 2005·Current Atherosclerosis Reports·Helena Gylling, Tatu A Miettinen
Jun 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·K NikkiläT A Miettinen
Aug 6, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Kozo OkadaSatoshi Umemura
Jan 13, 2010·Journal of Atherosclerosis and Thrombosis·Masaaki HoshigaToshiaki Hanafusa
Feb 14, 2013·Journal of Lipid Research·Scott M Grundy
Oct 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·P V Koivisto, T A Miettinen
Oct 6, 2009·Atherosclerosis·Oliver WeingärtnerDieter Lütjohann
May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K NikkiläT A Miettinen
Oct 1, 1988·Scandinavian Journal of Gastroenterology·K Nikkilä, T A Miettinen
Feb 26, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Monica GelzoGiuseppe Castaldo
Dec 13, 2006·The American Journal of Clinical Nutrition·Maarit HallikainenHelena Gylling
Jul 17, 2018·Current Medicinal Chemistry·Helena GyllingIngmar Wester
Jan 1, 2020·Lipids in Health and Disease·Monica GelzoAntonio Dello Russo
Sep 4, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shyamaladevi Babu, Selvaraj Jayaraman
Jan 31, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·H T Vanhanen, T A Miettinen

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