PMID: 25743809Mar 7, 2015Paper

Serum pleiotrophin could be an early indicator for diagnosis and prognosis of non-small cell lung cancer

Asian Pacific Journal of Cancer Prevention : APJCP
Zi-Yan DuYong Yu

Abstract

Pleiotrophin (PTN), an angiogenic factor, is associated with various types of cancer, including lung cancer. Our aim was to investigate the possibility of using serum PTN as an early indicator regarding disease diagnosis, classification and prognosis, for patients with non-small cell lung cancer (NSCLC). Significant differences among PTN levels in patients with small cell lung cancer (SCLC, n=40), NSCLC (n=136), and control subjects with benign pulmonary lesions (n=21), as well as patients with different pathological subtypes of NSCLC were observed. A serum level of PTN of 300.1 ng/ml, was determined as the cutoff value differentiating lung cancer patients and controls, with a sensitivity and specificity of 78.4% and 66.7%, respectively. Negative correlations between serum PTN level and pathological differentiation level, stage, and survival time were observed in our cohort of patients with NSCLC. In addition, specific elevation of PTN levels in pulmonary tissue in and around NSCLC lesions in comparison to normal pulmonary tissue obtained from the same subjects was also observed (n=2). This study suggests that the serum PTN level of patients with NSCLC could be an early indicator for diagnosis and prognosis. This conclusion sho...Continue Reading

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Citations

Oct 25, 2016·Biochimica Et Biophysica Acta·Evangelia PapadimitriouDimitris Beis
Jan 13, 2019·Journal of Cellular and Molecular Medicine·Chunhua XuXiuwei Zhang
Dec 30, 2017·International Journal of Molecular Medicine·Rui WangZhengxia Wu
Sep 28, 2017·Cancer Biomarkers : Section a of Disease Markers·Nicole M GiamancoJeffrey Baron
Apr 12, 2019·Interdisciplinary Sciences, Computational Life Sciences·Anil Kumar TomarBishwajit Kundu

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