Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn's Disease.

Scientific Reports
Elizabeth A ScovilleLori A Coburn

Abstract

Crohn's disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and adipokines. Serum was prospectively collected from 116 CD subjects and 27 non-IBD controls. Clinical disease activity was assessed by the Harvey Bradshaw Index (HBI). Serum fatty acids were measured by gas chromatography. Serum cytokines and adipokines were measured by Luminex assay. Dietary histories were obtained from a subset of patients. Nine serum cytokines and adipokines were increased in CD versus controls. CD subjects had increased percentage serum monounsaturated fatty acids (MUFA), dihomo-gamma linolenic acid (DGLA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and oleic acid, but decreased arachidonic acid (AA) versus controls. The % total n-3 fatty acids and % EPA directly correlated with pro-inflammatory cytokine levels and HBI, whereas the % total n-6 fatty acids were inversely correlated with pro-inflammatory cytokine levels and HBI. CD subjects had increased caloric intake versus control...Continue Reading

References

Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Oct 8, 2004·The British Journal of Nutrition·Paul Trayhurn, I Stuart Wood
Mar 9, 2005·The Journal of Experimental Medicine·Makoto AritaCharles N Serhan
Jan 19, 2007·Inflammatory Bowel Diseases·James JuppAnthony P Sampson
Jul 27, 2007·Nature·R J Xavier, D K Podolsky
Apr 10, 2008·JAMA : the Journal of the American Medical Association·Brian G FeaganPaul Rutgeerts
Apr 26, 2008·Nature Reviews. Immunology·Charles N SerhanThomas E Van Dyke
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Dan TurnerAnne Marie Griffiths
Jun 9, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Robert S ChapkinDavid N McMurray
Jul 15, 2009·British Journal of Pharmacology·Payal Kohli, Bruce D Levy
Jul 14, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Benjamin BertinLaurent Dubuquoy
Jan 19, 2013·Inflammatory Bowel Diseases·Rachel Marion-LetellierSubrata Ghosh
Jul 6, 2013·Gut·Ashwin N AnanthakrishnanAndrew T Chan
Mar 4, 2014·The Cochrane Database of Systematic Reviews·Raffi Lev-TzionDan Turner
Sep 2, 2015·European Journal of Pharmacology·Raquel Cristina SchwankeJoão B Calixto
Apr 17, 2016·European Journal of Pharmacology·Susan SergeantFloyd H Chilton
Apr 23, 2016·Inflammatory Bowel Diseases·Lori A CoburnKeith T Wilson
Apr 24, 2018·Metabolomics : Official Journal of the Metabolomic Society·Elizabeth A ScovilleLori A Coburn

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Citations

Nov 17, 2019·International Journal of Colorectal Disease·Yueying ChenJun Shen
May 11, 2019·Nutrients·Fernando RizzelloPaolo Gionchetti
Jan 30, 2021·Food Research International·Roberto de Paula do NascimentoMário Roberto Maróstica Junior
Mar 18, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jiayu YeDeanna L Gibson
May 27, 2021·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Pabitra SahuRakesh K Tandon
Jul 25, 2021·International Journal of Molecular Sciences·Haruki UsudaKoichiro Wada
Aug 12, 2021·Scientific Reports·Yuko AkazawaFuminao Takeshima
Oct 10, 2021·Oncogene·Dina PolosukhinaLori A Coburn
Oct 16, 2021·Shock·Allan E StolarskiDaniel G Remick

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Methods Mentioned

BETA
fatty acid profiling
serum collection
metabolomic profiling

Software Mentioned

GraphPad Prism
Nutrient Data System for Research

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