Abstract
To compare the clinical features of our sero-negative and sero-positive neuromyelitis optica (NMO) patients. Thirty-nine patients with NMO were recruited and analyzed retrospectively. Serum aquaporin 4 (AQP4) antibody status was determined by a cell-based assay. For the sero-negative patients, cerebrospinal fluid (CSF) and serum samples were re-tested using the cell-based assay and an indirect immunofluorescence assay. By the cell-based assay, 30 patients (76.92%, 30/39), were positive for AQP4 antibodies in serum and 37 patients (94.9%, 37/39), had a CSF-positive antibody status. Seven NMO patients (17.9%, 7/39) were sero-negative by the cell-based assay but demonstrated positive CSF results. By indirect immunofluorescence, the remaining two patients, who had no AQP4 antibodies in serum or CSF by the cell-based assay, were positive for IgG antibodies in serum, which selectively targeted the central nervous system microvessels, pia, subpia, Virchow-Robin space, kidney, and stomach. There were no significant differences between the sero-positive and sero-negative NMO groups among their demographic and clinical data. Repeating the test using a different assay or CSF is helpful to clarify whether sero-negative NMO patients do in f...Continue Reading
References
Nov 1, 1983·Neurology·J F Kurtzke
Jun 22, 2002·Brain : a Journal of Neurology·Claudia F LucchinettiHans Lassmann
Dec 14, 2004·Lancet·Vanda A LennonBrian G Weinshenker
Aug 10, 2005·The Journal of Experimental Medicine·Vanda A LennonShannon R Hinson
Mar 1, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·I NakashimaY Itoyama
May 24, 2006·Neurology·D M WingerchukB G Weinshenker
Apr 19, 2007·Brain : a Journal of Neurology·Takeshi MatsuokaJun-ichi Kira
Apr 24, 2007·Brain : a Journal of Neurology·Toshiyuki TakahashiYasuto Itoyama
Jan 23, 2008·Multiple Sclerosis : Clinical and Laboratory Research·Romain MarignierChristian Confavreux
Mar 13, 2008·Nature Clinical Practice. Neurology·Sven JariusBrigitte Wildemann
Apr 22, 2008·Multiple Sclerosis : Clinical and Laboratory Research·Q ChengS Fredrikson
Apr 25, 2008·Seminars in Ophthalmology·Sheri E HamnikWalter Jay
Apr 26, 2008·European Neurology·Mami KanzakiKeiko Kamakura
Mar 25, 2009·Neurology·E C KlawiterR T Naismith
May 26, 2009·Multiple Sclerosis : Clinical and Laboratory Research·T MatsushitaJ I Kira
Aug 12, 2009·Multiple Sclerosis : Clinical and Laboratory Research·R FazioG Martino
Nov 26, 2009·Annals of Neurology·Jeffrey L BennettBernhard Hemmer
Jul 20, 2010·Nature Reviews. Neurology·Sven Jarius, Brigitte Wildemann
Sep 10, 2010·Journal of Neuroinflammation·Sven JariusBrigitte Wildemann
May 19, 2011·Journal of Neurology·R LiX Hu
Citations
Nov 13, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yang YangQian Wu
Oct 15, 2013·Brain Pathology·Sven Jarius, Brigitte Wildemann
Jun 24, 2020·Multiple Sclerosis and Related Disorders·Krzysztof BarćBeata Zakrzewska-Pniewska