Serum-positive and -negative AQP4 antibody NMO in Chinese patients

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Youming LongXueqiang Hu

Abstract

To compare the clinical features of our sero-negative and sero-positive neuromyelitis optica (NMO) patients. Thirty-nine patients with NMO were recruited and analyzed retrospectively. Serum aquaporin 4 (AQP4) antibody status was determined by a cell-based assay. For the sero-negative patients, cerebrospinal fluid (CSF) and serum samples were re-tested using the cell-based assay and an indirect immunofluorescence assay. By the cell-based assay, 30 patients (76.92%, 30/39), were positive for AQP4 antibodies in serum and 37 patients (94.9%, 37/39), had a CSF-positive antibody status. Seven NMO patients (17.9%, 7/39) were sero-negative by the cell-based assay but demonstrated positive CSF results. By indirect immunofluorescence, the remaining two patients, who had no AQP4 antibodies in serum or CSF by the cell-based assay, were positive for IgG antibodies in serum, which selectively targeted the central nervous system microvessels, pia, subpia, Virchow-Robin space, kidney, and stomach. There were no significant differences between the sero-positive and sero-negative NMO groups among their demographic and clinical data. Repeating the test using a different assay or CSF is helpful to clarify whether sero-negative NMO patients do in f...Continue Reading

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Citations

Nov 13, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yang YangQian Wu

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