Serum pro-hepcidin levels and relationships with iron parameters in healthy preterm and term newborns

Pediatric Hematology and Oncology
Filiz TikerBerkan Gürakan

Abstract

A recently isolated peptide hormone, hepcidin, is thought to be the principal regulator of iron homeostasis. Hepcidin acts by limiting intestinal iron absorption and promoting iron retention in reticuloendothelial cells. Its precursor peptide form is called pro-hepcidin. The aims of this study were to determine serum pro-hepcidin levels in healthy preterm and term newborns, and to assess possible relationships between pro-hepcidin and serum iron, serum ferritin, and transferrin. A serum sample was collected from each of 26 healthy preterm (gestational age < 37 weeks) and 16 healthy, full-term, appropriate-for-gestational age babies. The preterm babies were also divided into 2 subgroups based on gestational age. Samples were analyzed for complete blood count, serum iron and ferritin concentrations, iron-binding capacity, and transferrin and pro-hepcidin levels. Group findings were compared and correlations between pro-hepcidin and the iron parameters were tested. The respective serum pro-hepcidin levels (mean +/- SD) in the 16 healthy term and 26 healthy preterm newborns were 482 +/- 371.9 ng/mL and 496.7 +/- 443.5 ng/mL. Analysis revealed no significant correlations between serum pro-hepcidin level and serum iron, serum ferriti...Continue Reading

References

Dec 13, 2000·The Journal of Biological Chemistry·C H ParkT Ganz
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·G NicolasS Vaulont
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gaël NicolasSophie Vaulont
Dec 5, 2002·Nutrition Reviews·Marianne Wessling-Resnick
Jan 28, 2003·Blood Cells, Molecules & Diseases·Gaël NicolasSophie Vaulont
Jan 6, 2004·The Journal of Nutrition·Weng-In Leong, Bo Lönnerdal
Apr 15, 2004·Gut·K J Robson
Apr 15, 2004·Gut·A P WalkerJ S Dooley

❮ Previous
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Citations

May 15, 2012·Cellular and Molecular Life Sciences : CMLS·Paweł LipińskiRafał R Starzyński
Nov 6, 2009·Journal of Perinatology : Official Journal of the California Perinatal Association·G AmarilyoD Mandel
Jul 7, 2007·Pediatric Hematology and Oncology·A BaloghB Vásárhelyi
Nov 5, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·H Tolga ÇelikŞule Yiğit
Jan 31, 2012·The Journal of Pediatrics·Katharina F MüllerAxel R Franz
Aug 31, 2010·Blood Cells, Molecules & Diseases·Barbra J SasuGraham Molineux
Oct 2, 2007·Blood Cells, Molecules & Diseases·Erika V Valore, Tomas Ganz
Nov 6, 2008·International Journal of Laboratory Hematology·F S OrhonN Akar
May 2, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Ece YapakçiBerkan Gürakan
Nov 1, 2012·European Journal of Haematology·Despina D BrianaAriadne Malamitsi-Puchner
Dec 9, 2009·International Journal of Laboratory Hematology·J BoinskaJ Kwapisz
Jan 8, 2013·Journal of Clinical Laboratory Analysis·Ayse DoganYildiz Dallar
Oct 9, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Artur SłomkaEwa Zekanowska
Jun 2, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Servet OzkirazNamik Ozbek
Jan 12, 2010·Orvosi hetilap·Adám BaloghBarna Vásárhelyi
Feb 29, 2016·Pediatrics and Neonatology·Sriparna BasuAshok Kumar
Oct 9, 2015·Clinical Medicine Insights. Pediatrics·Wafaa A Qasem, James K Friel
Sep 11, 2010·Pediatric Blood & Cancer·Junko KitajimaToshiro Hara
Jan 16, 2013·The Korean Journal of Hematology·Hyoung Soo ChoiHye Ran Yang
Dec 14, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Fotini StripeliLydia Kossiva
Oct 10, 2009·Journal of Pediatric Hematology/oncology·Ece YapakçiNamik Ozbek
Apr 7, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Magnus Domellöf
Dec 17, 2008·The American Journal of Clinical Nutrition·Melissa F YoungKimberly O O'Brien
Nov 5, 2016·Journal of Perinatal Medicine·Jacky HerzlichShmuel Arnon
Mar 6, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Catherine C CibulskisAmit M Mathur
Apr 2, 2009·Pediatrics·Keith J Collard

❮ Previous
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