Serum procalcitonin in the diagnosis and management of intra-abdominal infections

Expert Review of Anti-infective Therapy
Richard R Watkins, Tracy L Lemonovich

Abstract

The biomarker procalcitonin (PCT) has been used to diagnose and monitor a number of clinically significant infections. Serum levels of PCT are often increased in the presence of bacterial and fungal infections but not viral infections or noninfectious inflammation. Intra-abdominal infections (IAIs) are serious conditions that pose difficult challenges to physicians and the healthcare system. Researchers have evaluated PCT in the management of IAIs, both for diagnosis and for guiding antibiotic therapy. The studies have produced mixed results, leading to controversy on the utility of PCT in IAIs. PCT appears to be most useful in diagnosing postoperative infections and necrotizing pancreatitis. This review aims to summarize these data, explore the pathophysiology of PCT in sepsis from IAIs, discuss the strengths and weaknesses of PCT monitoring in IAIs, and provide guidance for the interpretation of PCT levels.

References

Nov 23, 2000·Intensive Care Medicine·K ReinhartM Meisner
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·S HarbarthUNKNOWN Geneva Sepsis Network
Jun 29, 2002·Scandinavian Journal of Clinical and Laboratory Investigation·M LindbergK S Bjerve
Nov 20, 2003·JAMA : the Journal of the American Medical Association·Jean ChastreUNKNOWN PneumA Trial Group
Jan 5, 2005·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·E BlabA Rokitansky
Jul 5, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D A KafetzisE Androulakakis
Dec 13, 2006·Annals of Emergency Medicine·Alan E JonesJeffrey A Kline
Jun 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas SolimanGabriela A Berlakovich
Oct 31, 2007·Langenbeck's Archives of Surgery·Nenad IvancevićMilos Zarković
Dec 20, 2007·Critical Care : the Official Journal of the Critical Care Forum·Roman ZazulaEva Kieslichova
Dec 22, 2007·American Journal of Respiratory and Critical Care Medicine·Vandack NobreJérôme Pugin
Apr 17, 2008·Digestive Diseases and Sciences·Kelvin Teck-Joo ThiaChoon-Jin Ooi
May 13, 2008·Intensive Care Medicine·H B ReithA Thiede
Dec 17, 2008·Surgery·Alexander R NovotnyBernhard Holzmann
Dec 19, 2008·Critical Care : the Official Journal of the Critical Care Forum·Peter SimonLillian L Emlet
Mar 18, 2009·Critical Care : the Official Journal of the Critical Care Forum·Pierre Emmanuel CharlesJean Pierre Quenot
Jun 6, 2009·Critical Care : the Official Journal of the Critical Care Forum·Marcel HochreiterStefan Schroeder
Aug 13, 2009·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Michael SandB Mann
Dec 26, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinJohn G Bartlett
Mar 9, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Maartje A J van den BroekFuat H Saner
Mar 20, 2010·Digestive Diseases and Sciences·Timothy M SchmittHugo J R Bonatti
Apr 28, 2010·Journal of Clinical Microbiology·David N Gilbert
Sep 10, 2010·The American Journal of Emergency Medicine·Karen Y Kwan, Alan L Nager
Dec 21, 2010·Transplantation Proceedings·A PerrakisV Müller
Jan 14, 2011·American Journal of Clinical Pathology·Stefan RiedelJonathan M Zenilman
Feb 11, 2011·Current Infectious Disease Reports·John C Marshall
Mar 16, 2011·The Journal of Antimicrobial Chemotherapy·Savitri KibeGavin Barlow
Aug 3, 2011·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Rune Aabenhus, Jens-Ulrik Stæhr Jensen

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Citations

Jan 26, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Hong-chang LiDian-xu Feng
Mar 14, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Tuna DemirdalSalih Atakan Nemli
Aug 1, 2013·Physiological Reviews·Kendra N IskanderDaniel G Remick
Oct 4, 2017·American Journal of Respiratory and Critical Care Medicine·Brendon P SciclunaTom van der Poll

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