Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study

Scientific Reports
Alexandra Maria KoenigIris-Tatjana Kolassa

Abstract

Childhood maltreatment (CM) can increase the risk of adverse health consequences in adulthood. A deeper insight in underlying biological pathways would be of high clinical relevance for early detection and intervention. The untargeted investigation of all detectable metabolites and lipids in biological samples represents a promising new avenue to identify so far unknown biological pathways associated with CM. Using an untargeted approach, liquid chromatography-mass spectrometry (LC-MS) was performed on peripheral blood serum samples collected three months postpartum from 105 women with varying degrees of CM exposure. Comprehensive univariate and multivariate statistical analyses consistently identified eight biomarker candidates putatively belonging to antioxidant-, lipid-, and endocannabinoid-associated pathways, which differentiated between women with and without CM. Classification algorithms allowed for clear prediction of the CM status with high accuracy scores (~80-90%). Similar results were obtained when excluding all women with a lifetime psychiatric diagnosis. In order to confirm the identities of these promising biomarker candidates, LC-MS/MS analysis was applied, confirming one of the metabolites as bilirubin IXa, a p...Continue Reading

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Citations

Mar 19, 2019·PloS One·Synthia H MellonOwen M Wolkowitz
Mar 6, 2019·Frontiers in Psychiatry·Christina BoeckIris-Tatjana Kolassa
Sep 12, 2019·Frontiers in Neuroscience·Zoe PapadopoulouMichaela D Filiou
Mar 1, 2019·Scientific Reports·Ryan G ShielsAndrew C Bulmer
Jan 20, 2021·Development and Psychopathology·Laura Ramo-FernándezIris-Tatjana Kolassa

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Software Mentioned

METLIN
PLS
LipidBlast
FINDER
CI
DA
MS
RF
DIAL

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