Serum profiles of C-C chemokines in acute myocardial infarction: possible implication in postinfarction left ventricular remodeling

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
J T ParissisD T Kremastinos

Abstract

C-C chemokines are essential factors in the recruitment and activation of leukocytes from the circulation into inflamed tissue and may play a role in ischemia-induced myocardial injury and left ventricular remodeling after acute myocardial infarction (AMI). We investigated the kinetics of three major C-C chemokines, macrophage chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1 alpha (MIP-1 alpha), and regulated on activation normally T cell expressed and secreted (RANTES), in the sera of AMI patients and correlated the findings with the severity of the disease. Serum levels of C-C chemokines were determined in 35 AMI patients by ELISA assays serially during the first week of hospitalization and 1 month after hospital admission. Patients (n = 18) with uncomplicated AMI (Killip class I) were classified as group A, patients (n = 17) with AMI complicated by heart failure manifestations (Killip classes II and III) were classified as group B, and 15 age-matched and sex-matched volunteers were used as healthy controls. A sustained increase in serum C-C chemokines was observed in both AMI groups during the 7-day hospitalization period. Peaks of these inflammatory factors were significantly higher in group B than in gr...Continue Reading

References

Oct 1, 1991·The Journal of Clinical Investigation·N A NelkenJ N Wilcox
Mar 1, 1994·Immunology Today·M Baggiolini, C A Dahinden
Feb 15, 1997·Lancet·D H Adams, A R Lloyd
Jan 1, 1997·Annual Review of Immunology·M BaggioliniB Moser
Jul 7, 1997·The Journal of Experimental Medicine·J H GongI Clark-Lewis
Mar 23, 2000·Cardiovascular Research·S SasayamaA Matsumori

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Citations

Feb 21, 2009·Current Atherosclerosis Reports·Carlos Gonzalez-Quesada, Nikolaos G Frangogiannis
Jun 25, 2003·International Journal of Cardiology·Stamatis AdamopoulosDimitrios Th Kremastinos
Sep 13, 2002·European Journal of Internal Medicine·John ParissisStamatis Adamopoulos
Mar 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·André TalvaniMauro M Teixeira
Jun 29, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rajendranath RamasawmyAnna C Goldberg
Oct 13, 2006·Antioxidants & Redox Signaling·Nikolaos G Frangogiannis
Apr 9, 2008·Stem Cells and Development·Robert J HenningVincent Delostia
May 25, 2011·European Heart Journal·Fabrizio MontecuccoFrançois Mach
Sep 30, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sebastian SzaboHans Martin Hoffmeister
Dec 23, 2006·Clinical and Experimental Pharmacology & Physiology·Mathias BruegelJoachim Thiery
Feb 8, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Rogelio ZamilpaMerry L Lindsey
Jun 2, 2009·Frontiers in Bioscience (Scholar Edition)·Marcin Dobaczewski, Nikolaos Georgios Frangogiannis
Apr 10, 2012·The American Journal of Cardiology·Marie FertinChristophe Bauters
Dec 23, 2009·Vascular Pharmacology·Bonnie K Surmi, Alyssa H Hasty
Oct 17, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hye Ryoun Jang, Hamid Rabb
Jun 19, 2007·European Journal of Internal Medicine·Małgorzata Kobusiak-ProkopowiczWalentyna Mazurek
Dec 8, 2010·British Journal of Pharmacology·K L JonesA P Davenport
Jul 14, 2006·International Journal of Cardiology·Yu-Hua Liao, Xiang Cheng
Nov 23, 2011·Biochemical Society Transactions·Nadine SuffeeAngela Sutton
Mar 8, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xue QinLiying Yuan
Aug 12, 2009·Journal of Molecular and Cellular Cardiology·Vincent BraunersreutherClaire Arnaud
Jul 16, 2008·Journal of Molecular and Cellular Cardiology·Saskia C A de JagerErik A L Biessen
Feb 15, 2015·European Heart Journal. Acute Cardiovascular Care·Ignacio M SeropianAntonio Abbate
Jun 2, 2016·Journal of the American Heart Association·Colleen M DeweyChad E Grueter
Dec 6, 2003·Circulation Research·Niels R VeillardFrançois Mach
Jan 27, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Erdal CavusogluJonathan D Marmur
Mar 13, 2010·Journal of Applied Physiology·Maria VistnesGeir Christensen
Jul 2, 2017·Scientific Reports·Jesse V JokerstPhillip C Yang
Apr 10, 2019·Lipids in Health and Disease·Liu MiaoJin-Zhen Wu
May 18, 2020·Journal of Cardiovascular Translational Research·Bijun Chen, Nikolaos G Frangogiannis

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