Serum prolactin, growth hormone, total corticoids, thyroid hormones and thyrotropine during serial therapeutic sleep deprivation

Biological Psychiatry
H KuhsR Tölle

Abstract

In 13 patients fulfilling DSM-III-R criteria for a major depressive episode, hormone serum levels were measured at 8 AM on the day before and on the first and second days after partial sleep deprivation (PSD) late in the night during a 4-week course of therapy with amitriptyline in combination with 6 PSDs. Prolactin, human growth hormone (HGH) and total corticoids were not influenced by PSD. In contrast, T3 and thyrotropine (TSH) were elevated significantly on the 1st day after PSD throughout the series, but T4 less regularly. Although TSH reverted regularly to baseline values on the 2nd day after PSD, i.e. after a full night's sleep, T3 remained elevated. The hormones under discussion do not predict the therapeutic PSD effect. Nor can any correlation be determined between endocrine and clinical changes on the 1st or 2nd day after PSD. In connection with findings from sleep deprivation research in animals and in healthy subjects, the results suggest that thyroid changes under PSD may be nonspecific and unrelated to antidepressive PSD effects.

References

Jan 1, 1978·Psychiatria Clinica·G A Rudolf, R Tölle
Apr 1, 1975·Journal of Psychiatric Research·R E Luria
Jul 11, 1992·Archives of General Psychiatry·M P SzubaL R Baxter
Apr 15, 1992·Biological Psychiatry·G HöflichR Schmidt
Aug 1, 1989·Psychiatry Research·W P KaschkaP Bratenstein
Mar 1, 1988·Biological Psychiatry·A Baumgartner, H J Haug
Nov 1, 1986·Psychiatry Research·A Baumgartner, H Meinhold
Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Nov 12, 1993·Neuroscience Letters·A Campos-BarrosA Baumgartner
Jan 15, 1993·Biological Psychiatry·R C SheltonP T Loosen

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Citations

Sep 25, 2001·Depression and Anxiety·B L Ringel, M P Szuba
Nov 22, 1997·Journal of Psychiatric Research·E SeifritzE Holsboer-Trachsler
Mar 19, 2013·Journal of Sleep Research·Sebastian M SchmidBernd Schultes
May 15, 2013·Journal of Affective Disorders·Adem AydinRagıp Balaharoglu
Jan 1, 1997·International Journal of Psychiatry in Clinical Practice·H Kuhs, R Töolle
Nov 11, 2017·Cancer Causes & Control : CCC·Tiffany A KatzLesley M Butler
Sep 8, 2010·Sleep·Lynn KesslerPlamen D Penev
Nov 25, 2016·International Journal of Endocrinology·Nanfang LiWeiwei Zhang
Jul 1, 2010·Expert Review of Neurotherapeutics·Ulrich-Michael HemmeterJürgen-Christian Krieg

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