Serum prolidase activity in idiopathic and ischemic cardiomyopathy patients.

Journal of Clinical Laboratory Analysis
Yusuf SezenNurten Aksoy

Abstract

Idiopathic and ischemic dilated cardiomyopathies (DCM) are the most common types of DCM, and both exhibit the same histopathological feature of fibrosis. Prolidase is an enzyme that serves a rate-limiting function in collagen turnover. Several studies have shown increased prolidase activity in fibrosis, though controversy persists. In this study, we measured prolidase enzyme activity in patients with idiopathic or ischemic DCM and in healthy controls, making this, to our knowledge, the first study to do so. What we found is that serumprolidase activity was significantly lower in both DCM groups relative to healthy volunteers and lower in ischemic DCM than idiopathic. These intriguing results could be attributed either to decreased collagen turnover in the heart tissues in which DCM develops, a result of diminished functional heart tissue, or to decreased physical activity levels among DCM patients stemming from their heart failure. Either way, further studies are needed to verify and clarify our results.

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Citations

Nov 13, 2013·Journal of Thrombosis and Thrombolysis·Ahmet CaliskanBinali Mavitas
Dec 22, 2011·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M VuralN Aksoy
Apr 20, 2012·Journal of Applied Microbiology·R L Kitchener, A M Grunden
Jun 28, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Roberta BesioAntonella Forlino
Mar 8, 2019·Combinatorial Chemistry & High Throughput Screening·Mustafa Begenc Tascanov
Sep 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sandra Carla RochaAriel Mariano Silber
Oct 23, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Paweł RubiśPiotr Podolec
Aug 22, 2017·Frontiers in Cardiovascular Medicine·Adnan SultanAndrew P DeFilippis
Sep 4, 2021·Medicine·Karina Silva-LunaAmbar López-Macay

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