Serum prostate-specific antigen in a community-based population of healthy Japanese men: lower values than for similarly aged white men

British Journal of Urology
J E OesterlingM M Lieber

Abstract

To determine whether the age-specific reference ranges for serum prostate-specific antigen (PSA) concentration generated for white men are applicable to other races. Three-hundred and thirty-five healthy Japanese men, aged 40-79 years, residing in the small fishing village of Shimamaki-mura, Japan, agreed to enter this prospective, community-based study. All underwent a detailed clinical evaluation that included a serum PSA determination, a digital rectal examination and a transrectal ultrasound. Two-hundred and eighty-six (85%) completed the prostatic evaluation and had no evidence of prostate cancer by any one of the three diagnostic tests; these men formed the study population on which all analyses were performed. The serum PSA concentration correlated directly with patient age (r = 0.33; P < 0.001) and prostatic volume (r = 0.57; P < 0.001). PSA density (PSAD) also was directly proportional to age (r = 0.30; P < 0.001). Adjusting for age, the serum PSA concentration was lower for Japanese men than for white men (P < 0.001). Thus, the recommended age-specific reference ranges (95th percentile) for serum PSA for Japanese were lower as well: 0.0-2.0 ng/mL for 40-49 years; 0.0-3.0 ng/mL for 50-59 years; 0.0-4.0 ng/mL for 60-69 ...Continue Reading

References

Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·N BreslowH Tulinius
Apr 22, 1992·JAMA : the Journal of the American Medical Association·H B CarterP C Walsh
May 1, 1991·The Journal of Urology·M K Terris, T A Stamey
May 1, 1973·Journal of the National Cancer Institute·K Akazaki, G N Stemmerman
Jan 5, 1970·JAMA : the Journal of the American Medical Association·L R ElvebackF R Keating
Sep 1, 1984·The Journal of Urology·S J BerryL L Ewing
Jan 1, 1994·The Journal of Urology·G G KleeJ E Oesterling
Jan 1, 1994·Journal of Clinical Laboratory Analysis·J T Wu
Jul 1, 1993·The Journal of Urology·C G ChuteM M Lieber
Aug 18, 1993·JAMA : the Journal of the American Medical Association·J E OesterlingM M Lieber

❮ Previous
Next ❯

Citations

Jul 23, 2011·World Journal of Urology·Seung Hwan LeeByung Ha Chung
Dec 26, 2001·Urology·S J JacobsenM M Lieber
Dec 4, 2008·Asian Journal of Andrology·Zhi-Yong LiuShan-Cheng Ren
May 16, 2002·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi OhigashiMasaru Murai
Aug 1, 1996·The New England Journal of Medicine·T O MorganJ W Moul
Aug 1, 1996·The New England Journal of Medicine·J E Oesterling
Jan 9, 1997·The New England Journal of Medicine·M W Jacobson
Feb 26, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·H MaedaY Arai
Aug 26, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·H MaedaS Maekawa
Oct 22, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·O OgawaT Kato
Aug 17, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Elijah O KehindeMathew P Abraham
Apr 1, 2010·Therapeutic Advances in Urology·Chaidir Arif Mochtar, R Siddhi Andika
Apr 1, 2007·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Arvind P GanpuleSharad Bapat
Jul 11, 2002·The Lancet Oncology·Herman Adlercreutz
Feb 16, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Woo Suk ChoiHwancheol Son
Mar 26, 2016·Nigerian Journal of Surgery : Official Publication of the Nigerian Surgical Research Society·S O IkuerowoO A Omisanjo
Dec 26, 2007·Urology·Ho Kyung SeoUNKNOWN Korean Urological Oncologic Society Prostate Cancer Study Group
Dec 26, 2007·Urology·Young Deuk ChoiWon Sik Ham
May 15, 2007·The Journal of Urology·Alexandre E PelzerWolfgang Horninger
Jun 12, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Taiji TsukamotoMartin M Crane
Aug 30, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Yong-June KimWun-Jae Kim
Oct 25, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Yong-June KimSang Eun Lee
May 2, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Taiji TsukamotoMartin M Crane
Oct 31, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Fumimasa FukutaTaiji Tsukamoto
Jun 15, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Hitoshi MasudaKazunori Kihara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.