Serum prostate specific antigen levels in women with polycystic ovary syndrome and the effect of flutamide+desogestrel/ethinyl estradiol combination

Journal of Endocrinological Investigation
M BahceciS Bahceci

Abstract

Prostate-specific antigen (PSA) is expressed in many female tissues and its concentrations were higher in hirsute subjects. We aimed to determine serum PSA level in hirsute women and evaluate the effect of flutamide+desogestrel/ethynil estradiol combination. Thirty patients with polycystic ovary syndrome (PCOS) and 30 healthy controls were studied. Hirsutism was defined by modified Ferriman-Gallwey score (FGS). Free androgen index (FAI) was used for hyperandrogenism. Patients received flutamide (500 mg/d) and oral contraceptive (desogestrel+ethinyl estradiol) for 9 months. Mean FGS (p<0.0001), insulin (p<0.01), FAI (0.0001), androstenedione (p<0.0001), LH (p<0.05), and free testosterone (p<0.003) levels of patients with PCOS were higher than the control group. Mean serum total and free PSA level of PCOS patients were higher than the control group (p<0.0001 and p<0.0001). We found a positive correlation between total PSA levels and FGS (r=0.568, p<0.001), FAI and FGS (r=0.456 and p<0.01). There was also a positive correlation between FAI and total PSA (r=0.503 and p<0.005). At the end of treatment, FGS, androstenedione, free and total testosterone, FAI, serum PSA and LH levels decreased significantly [serum total PSA was 0.0208 ...Continue Reading

References

Jan 16, 1995·The American Journal of Medicine·P D Darney
Mar 1, 1997·The Journal of Clinical Endocrinology and Metabolism·D N MelegosE P Diamandis
May 1, 1997·The Urologic Clinics of North America·E P Diamandis, H Yu
Apr 29, 1999·Journal of Endocrinological Investigation·I I Müderris, F Bayram
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Apr 12, 2001·The Journal of Clinical Endocrinology and Metabolism·C V ObiezuE P Diamandis
Nov 13, 2001·American Journal of Clinical Dermatology·L FalsettiL Legrenzi
Oct 26, 2002·Journal of Endocrinological Investigation·L ManettiE Martino
Nov 1, 1961·The Journal of Clinical Endocrinology and Metabolism·D FERRIMAN, J D GALLWEY

❮ Previous
Next ❯

Citations

Jul 19, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ewa RudnickaKatarzyna Suchta
Jun 11, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·F M CamachoI M Coronel-Pérez
Apr 1, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Eleftherios P DiamandisRicardo Azziz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Fertility and Sterility
H F Escobar-MorrealeJ Sancho
The Journal of Clinical Endocrinology and Metabolism
D N MelegosE P Diamandis
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
K GuzelmericC Turan
European Journal of Endocrinology
E Carmina
Acta Obstetricia Et Gynecologica Scandinavica
C Castelo-BrancoA Fortuny
© 2022 Meta ULC. All rights reserved