Serum protein electrophoresis: potential test for use in geriatric companion animal health programmes

Zentralblatt für Veterinärmedizin. Reihe A
E K BatamuziA L Jensen

Abstract

The electrophoretic patterns of 117 serum samples from 37 clinically healthy old dogs (age: 10.0 +/- 2.5 years, mean +/- SD) 47 old dogs (age: 9.7 +/- 2.0 years) with different diseases, 18 clinically healthy young dogs (age: 2.9 +/- 1.6 years) and 15 young dogs (age: 2.0 +/- 1.0 years) with different diseases were evaluated using agarose as a supporting matrix. Three major electrophoretic patterns were identified after densitometric scanning. The first pattern was a predominant pattern for the young healthy dogs (found in 67% of dogs in that group) and was considered normal for healthy dogs. The second pattern had relatively higher proportions of beta and gamma globulins (polyclonal immunoglobulinaemia) and was a predominant pattern among the old healthy dogs (found in 51% of dogs in that group). The findings regarding the second pattern appear to suggest that they had been exposed to antigens during their lives and that they had a well developed and responsive humoral immune response. The third pattern was characterized by high levels of alpha globulins, it was the most common pattern in the old diseased dogs (found in 70% of the dogs in that group). The third pattern was considered to indicate an inflammatory response among ...Continue Reading

References

Jul 1, 1992·The British Veterinary Journal·J Kent
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Citations

Sep 29, 2009·Ecology Letters·Daniel R MacNultyCraig Packer
Aug 12, 1998·The Veterinary Record·E K BatamuziA L Jensen
Jul 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marta Bellodi-PrivatoNicolas Ferry

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