Serum proteomic analysis of the anti‑arthritic effects of sinomenine on rats with collagen‑induced arthritis

Molecular Medicine Reports
Xin QianHui Cai

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease, which is characterized by inflammatory synovitis, and the subsequent destruction of articular cartilage and bone. Sinomenine is a traditional Chinese medicine, which has been employed as a clinical treatment for RA for several years in China. The present study investigated the anti‑arthritic effects of sinomenine on Sprague‑Dawley rats with collagen‑induced arthritis (CIA). The differentially expressed proteins in serum were measured by proteomic analysis in order to generate a differentially expressed protein network. A total of 320 differentially expressed proteins were detected in the drug‑treated group compared with in the control group. In the sinomenine‑treated group, 79 differentially expressed proteins were detected compared with in the model group, and among these, 46 proteins were upregulated. Gene ontology analysis revealed that five functions were affected by sinomenine treatment of CIA rats compared with in the model group. In addition, Ingenuity® Pathway Analysis was used to measure enriched signaling pathways, which revealed nuclear factor‑κB, histones, heat shock proteins and protein kinase B as core proteins, generating ~60 pair associations in the network. To...Continue Reading

References

Jan 24, 2002·Nature·Anuj Kumar, Michael Snyder
Aug 15, 2002·Annals of the Rheumatic Diseases·Y SugiuraR Ueda
Jun 5, 2007·Nature Protocols·David D BrandEdward F Rosloniec
Oct 29, 2008·Oncogene·T F Franke
Feb 10, 2009·Nature Methods·Alexander WepfMatthias Gstaiger
Nov 27, 2010·International Immunopharmacology·Quanxing Wang, Xiao-Kang Li
Feb 22, 2011·Mass Spectrometry Reviews·Delphine PfliegerAlberto de la Fuente
Jun 19, 2012·Journal of Autoimmunity·Marie-Christophe BoissierGéraldine Falgarone
Dec 22, 2012·Current Protocols in Pharmacology·Susan Jones-Bolin
Oct 10, 2013·Journal of Microbiology and Biotechnology·Ran NohByoung Chul Park
Apr 12, 2016·Basic & Clinical Pharmacology & Toxicology·Lizhi FengLinlin Lu
Apr 26, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Biao ZhouHui Xiong
Jun 16, 2017·Nature Reviews. Rheumatology·Gerd R BurmesterIain B McInnes
Aug 2, 2017·Microbial Pathogenesis·Haifeng YangYiyi Hu

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Citations

May 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Xuan XiaQingchun Huang

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Methods Mentioned

BETA
chip

Software Mentioned

Ingenuity ® Pathway Analysis ( IPA )
MaxQuant
IPA
SPSS

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