Serum proteomic profiling of obese patients: correlation with liver pathology and evolution after bariatric surgery

Gut
V Trak-SmayraV Paradis

Abstract

Chronic liver diseases, including cirrhosis, may develop in obese patients. Steatosis and non-alcoholic steatohepatitis (NASH) are risk factors for progression to fibrosis. To date, diagnosis of steatosis and NASH relies on liver biopsy. The aim of the study was to identify serum markers of steatosis and NASH in obese patients using SELDI-TOF ProteinChip. Eighty obese non-alcoholic patient candidates for bariatric surgery and devoid of hepatitis B and C infection were selected. Serum samples were collected before surgery and at 6 months after surgery for 33 of these patients. Wedge liver biopsy was performed at the time of bariatric surgery. Twenty-four serum samples from healthy blood donors served as controls. The protein profiles of each serum were assessed using SELDI-TOF ProteinChip technology and were compared according to liver histological lesions. Twenty-four obese patients (30%) had non-significant liver lesions, 32 (40%) had significant steatosis and 24 (30%) had NASH. Comparison of serum protein profiles according to liver lesions identified three peaks (CM10-7558.4, CM10-7924.2 and Q10-7926.9) the intensity of which significantly increased according to the severity of the liver lesions (steatosis and NASH) and retu...Continue Reading

Citations

Nov 21, 2013·Biomarker Research·Steven G PearceJen-Jung Pan
Sep 19, 2009·World Journal of Gastroenterology : WJG·Yusuf YilmazOsman Ozdogan
May 19, 2010·Biomarkers in Medicine·Vlad RatziuThierry Poynard
Dec 12, 2012·Biomarkers in Medicine·Francesco Di GirolamoLorenza Putignani
Mar 8, 2012·Journal of Pediatric Gastroenterology and Nutrition·Pietro VajroValerio Nobili
Dec 30, 2014·Scandinavian Journal of Gastroenterology·Umit AkyuzYusuf Yilmaz
Dec 4, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Anca LădaruIoana Alina Anca
Sep 15, 2011·European Journal of Clinical Investigation·Yusuf YilmazCem Kalayci
Jan 1, 2012·Journal of Clinical Laboratory Analysis·Annemieke W J Opstal-van WindenCarla H van Gils
Mar 9, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Michael H MillerJohn F Dillon
Mar 22, 2016·International Journal of Molecular Sciences·Natalia Nuño-LámbarriNorberto C Chávez-Tapia
May 2, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yusuf Yilmaz
Sep 8, 2016·Journal of Translational Medicine·Dominique de SenyMichel G Malaise
Mar 5, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Julia WattacherilCharles Robb Flynn
Aug 26, 2014·World Journal of Gastroenterology : WJG·Emer Fitzpatrick, Anil Dhawan
Sep 13, 2018·Scientific Reports·Yizhao ShenZhonghua Wang
Feb 10, 2017·Journal of Gastroenterology and Hepatology·Ya-Jie LinXiao-Peng Fan
Jul 25, 2017·Journal of Pediatric Gastroenterology and Nutrition·Valentina GiorgioLuca Miele
Jun 7, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Stefania Di MauroSalvatore Piro
Jul 11, 2018·International Journal of Molecular Sciences·Sung-Hui TsengJung-Su Chang

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