Serum PTHrP Predicts Weight Loss in Cancer Patients Independent of Hypercalcemia, Inflammation, and Tumor Burden

The Journal of Clinical Endocrinology and Metabolism
Namki HongHyun Chul Lee

Abstract

Recent animal studies showed that tumor-derived PTHrP induced cancer cachexia by fat browning with increased energy expenditure; however, clinical evidence from human data is insufficient. We investigated whether serum PTHrP levels independently predicts weight loss (WL) in cancer patients. From a longitudinal observational cohort, body mass index (BMI) of patients with measured serum PTHrP levels (n = 624) was assessed (median follow-up of 327 d). Cox hazard models were used to examine the predictive value of PTHrP for WL defined by consensus definition (WL [consensus], percentage WL < -5% or percentage WL < -2% plus BMI < 20 kg/m(2)) and by BMI-adjusted grades (WL [BMI adjusted]). The overall risk of WL (consensus) was 34.4%. Compared with PTHrP-negative subjects, patients with higher PTHrP levels (PTHrP ≥ median 5.7 pmol/L) had more WL (percentage WL, -6.9% vs -1.1%, P = .010) at follow-up. A higher PTHrP level was associated with an increased loss of body weight (β = -2.73), muscle (β = -1.85), and fat (β = -2.52) after controlling for age, sex, and BMI. Kaplan-Meier analysis demonstrated that subjects with higher PTHrP had increased WL risk compared with lower PTHrP or PTHrP-negative groups (52.0% vs 38.9% vs 29.7%, P < .0...Continue Reading

Citations

Jan 19, 2018·Nature Reviews. Disease Primers·Vickie E BaracosKenneth C H Fearon
Oct 12, 2019·International Journal of Molecular Sciences·Rogier L C PlasKlaske van Norren
Jan 11, 2020·Frontiers in Oncology·Hannes ZwicklMartin Pecherstorfer
Nov 1, 2017·Porto Biomedical Journal·Rita FerreiraDaniel Moreira-Gonçalves
Oct 15, 2020·Journal of Cachexia, Sarcopenia and Muscle·Adeline DollyStéphane Servais
Mar 31, 2021·Molecular and Cellular Endocrinology·Pedro CarriereClaudia Gentili
May 1, 2021·International Journal of Molecular Sciences·Zhipeng CaoLaura D Osellame
Jun 2, 2021·Journal of Cachexia, Sarcopenia and Muscle·Hirotaka KomabaMasafumi Fukagawa

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