Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate

Arthritis Research & Therapy
Aase Haj HensvoldAnca I Catrina

Abstract

Receptor activator of nuclear factor kappa B ligand (RANKL) is a key regulator of bone metabolism. Anti-citrullinated protein antibodies (ACPA) have been suggested to cause bone destruction by osteoclast activation. We investigated the relationship between RANKL and ACPA in patients with early untreated rheumatoid arthritis (RA). Patients with newly diagnosed untreated RA (n = 183) were analyzed at baseline and 3 months after initiating methotrexate (MTX) treatment. Serum RANKL (total RANKL), ACPA (anti-CCP2) and ACPA specificities (anti-citrullinated (cit)-vimentin, anti-cit-enolase and anti-cit-fibrinogen) were determined by enzyme-linked immunosorbent assay (ELISA). Synovial RANKL expression was evaluated by immunohistochemistry in a small group of patients (n = 15). The relationship between anti-cit-vim antibodies and bone destruction was further validated in 1116 RA patients included in the EIRA cohort. Pearson's chi-square test, Wilcoxon rank sum test, Wilcoxon signed rank test and linear regression models were used. Serum RANKL concentration was significantly higher (p <0.05) in ACPA-positive (median: 689 pmol/L, IQR 342-1253) compared with ACPA-negative (median: 159 pmol/L, IQR 96-243) patients and this difference was a...Continue Reading

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Citations

May 12, 2016·Clinical Reviews in Allergy & Immunology·Sofia Carvalho Barreira, João Eurico Fonseca
May 20, 2016·BoneKEy Reports·Patrizia D'Amelio, Francesca Sassi
Nov 23, 2016·Expert Opinion on Biological Therapy·Yahui Grace Chiu, Christopher T Ritchlin
Dec 16, 2016·Nature Reviews. Rheumatology·Anca I CatrinaLars Klareskog
Jul 14, 2017·Nature Reviews. Rheumatology·Carl OrrSander W Tas
Aug 11, 2017·Arthritis Research & Therapy·Susanna L LundströmAnca I Catrina
Oct 21, 2016·Current Opinion in Rheumatology·Bryant R EnglandTed R Mikuls
Jun 1, 2019·Scientific Reports·Paul M LübckeBrigitte Müller-Hilke
Dec 15, 2020·Arthritis & Rheumatology·Josephine A M P AmkreutzDiane van der Woude

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
sandwich immunoassay
biopsies

Software Mentioned

SAS

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