Serum Renalase Levels in Adolescents with Primary Hypertension

Pediatric Cardiology
Marta LemieszAnna Wasilewska

Abstract

The prevalence of hypertension in pediatric populations continues to rise. Recent studies suggest that renalase plays an important role in blood pressure regulation. The aim of this study was to evaluate serum renalase concentrations in hypertensive children. This study was a prospective cohort analysis of 88 adolescents (40 girls; 48 boys) aged 11-18 years, divided into two groups: HT-38 subjects with primary hypertension; and R (reference group)-50 subjects with normal blood pressure. Serum renalase concentration was measured using a commercial enzyme-linked immunosorbent assay kit. Hypertensive patients had higher serum renalase levels (median 29.8 µg/mL; Q1-Q3: 26.1-35.8) than the reference group (median 26.8; Q1-Q3: 22.96-29.4, p < 0.01). Serum renalase was strongly related to serum uric acid levels. In hypertensive patients, serum renalase was positively correlated with 24-h systolic blood pressure (SBP) and 24-h diastolic blood pressure (DBP) and with 24-h SBP and 24-h DBP Z-score (LMS). Our results allow us to conclude that serum renalase correlates with blood pressure elevation. Special attention should be drawn to the correlation between renalase and serum uric acid levels not only in hypertensive, but also in normote...Continue Reading

References

Dec 1, 1996·The American Journal of Physiology·Y AokiP A Jose
Oct 3, 2002·Journal of Hypertension·Elke WühlUNKNOWN German Working Group on Pediatric Hypertension
Aug 6, 2003·Hypertension·Daniel I Feig, Richard J Johnson
Apr 21, 2005·Kidney International·Uday M KhoslaRichard J Johnson
Apr 21, 2005·The Journal of Clinical Investigation·Jianchao XuGary V Desir
Oct 28, 2005·Journal of the American Society of Nephrology : JASN·Duk-Hee KangRichard J Johnson
Jan 12, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Qi ZhaoDongfeng Gu
Feb 16, 2008·Current Opinion in Nephrology and Hypertension·Gary V Desir
Nov 26, 2010·Current Opinion in Nephrology and Hypertension·Gary V Desir
Oct 18, 2011·Seminars in Nephrology·Young Hee RhoHyon K Choi
Jul 26, 2012·Journal of Hypertension·Zbigniew KułagaUNKNOWN OLAF Study Group
Nov 7, 2012·Journal of the American Heart Association·Gary V DesirHeino Velazquez
Jul 30, 2014·Journal of the American Society of Hypertension : JASH·Maciej T WybraniecAndrzej Więcek
Sep 26, 2015·Journal of the American Society of Hypertension : JASH·Dominika MaciorkowskaJolanta Malyszko
Jul 6, 2017·Clinical and Experimental Hypertension : CHE·Hui ZhouJinjiao Zhao

❮ Previous
Next ❯

Citations

Jul 12, 2019·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Piotr SkrzypczykMałgorzata Pańczyk-Tomaszewska
Jun 4, 2019·Journal of Medical Biochemistry·Zekiye CatakSuleyman Aydin
Feb 28, 2020·Experimental Biology and Medicine·Na-Na YouHui-Ting Tang
Jul 3, 2021·International Journal of Environmental Research and Public Health·Magda WiśniewskaAndrzej Pawlik

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Statistica

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.