PMID: 8951741Dec 1, 1996Paper

Serum response of all-trans and 9-cis isomers of beta-carotene in humans

Journal of the American College of Nutrition
E J JohnsonR M Russell

Abstract

Little work has been performed on the serum response of various carotene isomers. The present study was carried out to examine the serum response of all-trans and 9-cis isomers of beta-carotene (BC) using frequent blood sample collections at early time points. Serum responses of all-trans BC and a mixture of BC isomers containing 80% 9-cis BC were studied in 15 men by measuring the serum concentrations of BC at 1, 3, 5, 7, 9, 12, and 24 hours after a single large oral dose of all-trans BC or 9-cis BC. The serum response to an oral dose of all-trans BC (120 mg) significantly increased from baseline at 24 hr (p < 0.004). After an oral dose of a mixture of BC isomers (120 mg, 80% 9-cis BC), the peak concentration of 9-cis BC was significantly greater that baseline values (p < 0.016). Increases in serum all-trans BC levels, in part, may be due to greater intestinal absorption, whereas the inability to measure a significant increase in the concentration of 9-cis BC may indicate poor absorption, isomerization to all-trans BC, or a very rapid tissue uptake.

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Citations

Jan 17, 2007·Applied Microbiology and Biotechnology·R RajaR Rengasamy
Jul 24, 2002·Nutrition in Clinical Care : an Official Publication of Tufts University·Elizabeth J Johnson
Jul 9, 2010·International Journal of Food Sciences and Nutrition·Khairia M Al-Ahmary
Jun 11, 2002·Annual Review of Nutrition·Kyung-Jin Yeum, Robert M Russell
Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Masaki HondaMotonobu Goto
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I Cantuti-CastelvetriJ A Joseph
Feb 2, 2002·The Journal of Nutrition·Ahmad SulaemanJudy A Driskell
Mar 11, 2021·Journal of Agricultural and Food Chemistry·Masaki HondaIkuo Kuroda
Nov 29, 2005·Molecular Aspects of Medicine·Norman I Krinsky, Elizabeth J Johnson
Nov 24, 1999·Journal of Agricultural and Food Chemistry·K H van het HofJ A Weststrate
Jul 18, 2021·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sang-Ah LeeXiao-Ou Shu

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