Serum retinol-binding protein 4 is associated with insulin resistance in patients with early and untreated rheumatoid arthritis

Joint, Bone, Spine : Revue Du Rhumatisme
Yanlin WeiLei Yang

Abstract

Retinol-binding protein 4 (RBP4), systemic inflammation and insulin resistance (IR) are linked, yet the determinants of RBP4 and its impact on IR in rheumatoid arthritis (RA) are incompletely understood. The aim of this study was to explore the prevalence of IR in RA and investigate whether the serum levels of RBP4 were associated with IR in patients with RA. In this study, 403 individuals with newly diagnosed and untreated RA were consecutively recruited. We calculated the Disease Activity Score assessed using 28-joint counts for swelling and tenderness (DAS28). Levels of serum RBP4, interleukin-6 (IL-6) and tumor necrosis factor (TNF) α were tested. IR was defined as Homeostasis model assessment for insulin resistance (HOMA-IR) index greater than or equal 2.40. In those 403 patients, 68 (16.9%) were male and the median age was 43 years (IQR: 36-52). There was an evidently positive correlation between increased serum levels of RBP4 and increasing severity of RA (DAS28) (r = 0.403, P < 0.001). Furthermore, a modest positive correlation between levels of serum RBP4 and HOMA-IR score (r = 0.251; P < 0.0001) was found. Eighty-five patients (21.1%) in patients with RA were defined as IR (HOMA-IR ≥ 2.40), which was significantly hig...Continue Reading

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Citations

Jul 29, 2020·International Journal of Molecular Sciences·Anna Maria RychterIwona Krela-Kaźmierczak
Feb 27, 2021·Archives of Medical Research·Ali TaylanBahar Engin
May 22, 2021·Current Problems in Cardiology·Qingtong Wang Wei Wei

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