Serum S-100b protein as a biomarker for the assessment of neuroprotectants

Brain Research
Yasufumi ShirasakiToshiyuki Sato

Abstract

The study of biomarkers associated with stroke has proved to be of considerable utility. The astroglial protein S-100b is a candidate marker for cerebral tissue damage. We used a rat embolic model produced by injection of microspheres to demonstrate that serum S-100b is a useful biochemical marker for ischemic brain injury. Serum S-100b levels were significantly increased following microsphere injection, which was closely correlated with the development of brain edema. We found that structurally and mechanistically independent neuroprotective agents, such as 3-[2-[4-(3-chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, and the N-methyl-d-aspartate (NMDA) receptor antagonist MK-801, are capable of attenuating increased serum S-100b levels and brain edema. In contrast, the hyperosmolar agent glycerol, which has no direct neuroprotective action, had little effect on serum S-100b levels, despite a significant decrease in brain water content. These results suggest that lowering of serum S-100b is mediated by neuroprotection against ischemic brain injury. Thus, serum S-100b reflects the extent of brain damage followi...Continue Reading

References

Jan 1, 1979·Stroke; a Journal of Cerebral Circulation·A M BraletJ Bralet
Oct 1, 1991·European Journal of Clinical Investigation·R T CunninghamK D Buchanan
Sep 1, 1990·Trends in Pharmacological Sciences·B Meldrum, J Garthwaite
Dec 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C M PiconeJ Dedman
Jun 1, 1984·Journal of Neurochemistry·V E ShashouaB W Moore
Feb 25, 1982·Brain Research·K StefanssonB W Moore
Feb 1, 1995·Trends in Neurosciences·D W Choi
Jan 1, 1995·Brain Research Bulletin·D B ZimmerW Song
Apr 1, 1996·European Journal of Clinical Investigation·R T CunninghamK D Buchanan
Jan 20, 1997·Neuroreport·X SunA J Windebank
Jul 1, 1997·Annals of Clinical Biochemistry·H D AbrahaR A Sherwood
Feb 12, 1998·European Journal of Pharmacology·M SugimuraY Shirasaki
Mar 20, 1998·Stroke; a Journal of Cerebral Circulation·R J ButterworthP M Bath
Mar 27, 1999·European Journal of Clinical Investigation·H StevensJ Korf
Sep 15, 1999·Neurochemical Research·C W Heizmann
Apr 13, 2001·Emergency Medicine Journal : EMJ·C J Gordon
May 15, 2001·Life Sciences·A PalfiK Gulya
Nov 3, 2001·Stroke; a Journal of Cerebral Circulation·J Losy, J Zaremba
Nov 7, 2001·Acta Neurologica Scandinavica·J Zaremba, J Losy
Jun 5, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Toru MatsuiTakao Asano
Jan 4, 2003·Stroke; a Journal of Cerebral Circulation·Mar CastellanosAntoni Dávalos
Feb 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·C FoerchM Sitzer
May 17, 2003·Stroke; a Journal of Cerebral Circulation·Ji Hoe HeoJeong Mo Nam
Jun 5, 2003·Experimental Neurology·Masatoshi YunokiKevin S Lee
Jul 2, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Keiko Takagi, Satoshi Takeo
Jul 12, 2003·Journal of Neurosurgery·Sònia AbilleiraJosé Alvarez-Sabín
Sep 23, 2003·Clinical Chemistry·Mark A ReynoldsKenneth F Buechler
Nov 25, 2003·Stroke; a Journal of Cerebral Circulation·Marjaana TiainenOlli Takkunen
Dec 10, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Joan MontanerJosé Alvarez-Sabín

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Citations

Oct 31, 2007·Neurocritical Care·David L NashLatha G Stead
Apr 2, 2005·Biological & Pharmaceutical Bulletin·Masunobu SugimuraYasufumi Shirasaki
May 20, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert SimanRobert W Neumar
May 25, 2018·The International Journal of Neuroscience·Yongli HeYangmei Chen
Apr 1, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Maria JastrzębskaPrzemysław Nowacki
Apr 25, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Hamza AyaydınŞermin Bilgen Ulgar
Jul 11, 2019·Neural Regeneration Research·Nan-Xing YiTing Zhang
Nov 26, 2020·Pathogens and Disease·Thekra KhushafaZhu Haixia

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