Serum S100B Levels Can Predict Computed Tomography Findings in Paediatric Patients with Mild Head Injury

BioMed Research International
Fatos M KelmendiAfrim Kotori

Abstract

Traumatic brain injuries (TBIs) are very common in paediatric populations, in which they are also a leading cause of death. Computed tomography (CT) overuse in these populations results in ionization radiation exposure, which can lead to lethal malignancies. The aims of this study were to investigate the accuracy of serum S100B levels with respect to the detection of cranial injury in children with mild TBI and to determine whether decisions regarding the performance of CT can be made based on biomarker levels alone. This was a single-center prospective cohort study that was carried out from December 2016 to December 2017. A total of 80 children with mild TBI who met the inclusion criteria were included in the study. The patients were between 2 and 16 years of age. We determined S100B protein levels and performed head CTs in all the patients. Patients with cranial injury, as detected by CT, had higher S100B protein levels than those without cranial injury (p < 0.0001). We found that patients with cranial injury (head CT+) had higher mean S100B protein levels (0.527 μg L-1, 95% confidence interval (CI) 0.447-0.607 μg L-1) than did patients without cranial injury (head CT-) (0.145 μg L-1, 95% CI 0.138-0.152 μg L-1). Receiver oper...Continue Reading

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Citations

Apr 19, 2020·Journal of Neurotrauma·Rebekah MannixTimothy B Meier
Jun 26, 2021·Neurosurgical Review·Lucas Alexandre Santos MarzanoAline Silva de Miranda

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT02988102

Software Mentioned

SPSS Statistics

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