Sep 15, 2009

Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004

Environmental Health Perspectives
Martin LaclaustraEliseo Guallar

Abstract

Increasing evidence suggests that high selenium levels are associated with diabetes and other cardiometabolic risk factors. We evaluated the association of serum selenium concentrations with fasting plasma glucose, glycosylated hemoglobin levels, and diabetes in the most recently available representative sample of the U.S. population. We used a cross-sectional analysis of 917 adults > or = 40 years of age who had a fasting morning blood sample in the National Health and Nutrition Examination Survey 2003-2004. We evaluated the association of serum selenium, measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry, and diabetes, defined as a self-report of current use of hypoglycemic agents or insulin or as fasting plasma glucose > or = 126 mg/dL. Mean serum selenium was 137.1 microg/L. The multivariable adjusted odds ratio [95% confidence interval (CI)] for diabetes comparing the highest quartile of serum selenium (> or = 147 microg/L) with the lowest (< 124 microg/L) was 7.64 (3.34-17.46). The corresponding average differences (95% CI) in fasting plasma glucose and glycosylated hemoglobin were 9.5 mg/dL (3.4-15.6 mg/dL) and 0.30% (0.14-0.46%), respectively. In spline regression models, the prevalence of di...Continue Reading

  • References21
  • Citations94

References

  • References21
  • Citations94

Citations

Mentioned in this Paper

Glycated Hemoglobin TEST
Prevalence Studies
Hemoglobin, Glycosylated
Selenium
Plasma Fasting Glucose Measurement
Mass Spectrometry
Selenium Measurement
National Health and Nutrition Examination Survey
Glucohemoglobin Measurement
Selenium supplement

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