PMID: 15226462Jul 1, 2004Paper

Serum selenium is associated with plasma homocysteine concentrations in elderly humans

The Journal of Nutrition
Sonia GonzálezCristina Lasheras

Abstract

Low selenium levels in humans have been associated with several pathologies; however, an earlier animal investigation found a direct association between Se intake and total plasma homocysteine (tHcy) concentrations. To date, the importance of serum selenium levels in association with tHcy in humans has not been determined. We evaluated the cross-sectional association of blood selenium concentrations with plasma tHcy and other determinants of this cardiovascular disease risk factor. We estimated protein intake and measured the blood status of selenium, tHcy, and several other related factors in serum such as folate, vitamin B-12, and creatinine. Serum selenium was inversely associated with tHcy, explaining 5.8% of tHcy variance with respect to 2.2% accounted for by serum folate. Furthermore, there was a 63% decreased risk of higher tHcy concentrations (>14 micro mol/L) for subjects with serum selenium in the highest tertile (P = 0.013). We also found an inverse association of protein intake with tHcy in men (beta = -0.144; P = 0.036), which disappeared after controlling for serum Se concentrations (beta = -0.055; P = 0.003). In conclusion, selenium should be considered as a potential factor to lower tHcy. In addition, the descri...Continue Reading

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Citations

Aug 25, 2005·European Journal of Clinical Nutrition·M WoltersA Hahn
Mar 13, 2014·Journal of the American College of Nutrition·Nuria SalazarMiguel Gueimonde
Mar 21, 2007·The British Journal of Nutrition·Sonia GonzálezCristina Lasheras
Sep 23, 2011·The British Journal of Nutrition·Gerald F CombsJohn A Milner
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Nov 22, 2019·Reviews in the Neurosciences·Thomas BerryAhmed A Moustafa
Jan 5, 2006·Annals of Nutrition & Metabolism·Sonia GonzálezCristina Lasheras
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