Serum serotonin levels in patients with epileptic seizures

Epilepsia
Arun MurugesanSamden Lhatoo

Abstract

Profound cardiovascular and/or respiratory dysfunction is part of the terminal cascade in sudden unexpected death in epilepsy (SUDEP). Central control of ventilation is mediated by brainstem rhythm generators, which are influenced by a variety of inputs, many of which use the modulatory neurotransmitter serotonin to mediate important inputs for breathing. The aim of this study was to investigate epileptic seizure-induced changes in serum serotonin levels and whether there are potential implications for SUDEP. Forty-one epileptic patients were pooled into 2 groups based on seizure type as (1) generalized tonic-clonic seizures (GTCS) of genetic generalized epilepsy and focal to bilateral tonic-clonic seizures (FBTCS; n = 19) and (2) focal seizures (n = 26) based on clinical signs using surface video-electroencephalography. Postictal serotonin levels were statistically significantly higher after GTCS and FBTCS compared to interictal levels (P = .002) but not focal seizures (P = .941). The change in serotonin (postictal-interictal) was inversely associated with a shorter duration of tonic phase of generalized seizures. The interictal serotonin level was inversely associated with a shorter period of postictal generalized electroence...Continue Reading

References

Feb 24, 2005·Psychopharmacology·Jeffrey L RauschJoseph Smith
Aug 24, 2010·Molecular Interventions·Charles P Mercado, Fusun Kilic
Sep 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gordon F Buchanan, George B Richerson
Oct 1, 2010·Annals of Neurology·Samden D LhatooJonathan M Bird
Nov 30, 2010·Journal of Veterinary Science·Daniela AlberghinaGiuseppe Piccione
Jan 19, 2011·Epilepsia·George B Richerson, Gordon F Buchanan
Jan 2, 2013·Neuroscience Letters·Wan-Hui LinJi-Lan Lin
Aug 12, 2014·The Journal of Physiology·Gordon F BuchananGeorge B Richerson
Dec 3, 2014·Seminars in Cell & Developmental Biology·E A van VlietJ A Gorter
Jan 7, 2015·Cold Spring Harbor Perspectives in Biology·Richard Daneman, Alexandre Prat
Sep 30, 2015·Neurology·Nitin K SethiPhilippe Ryvlin
Aug 30, 2016·Lancet Neurology·Orrin DevinskyGeorge Richerson

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Citations

Jan 30, 2019·Current Opinion in Neurology·Philippe RyvlinSamden D Lhatoo
Apr 10, 2020·Expert Review of Neurotherapeutics·Max Christian PenselRainer Surges
Aug 28, 2020·Inflammatory Bowel Diseases·Christopher R ManzellaRavinder K Gill
Jan 9, 2019·Frontiers in Neurology·Benton S PurnellGordon F Buchanan
Dec 2, 2020·Life Sciences·Enes AkyuzYam Nath Paudel
Dec 24, 2019·Experimental Neurology·Alexandra N PetrucciGordon F Buchanan
Jan 16, 2021·The Journal of International Medical Research·Liang ZhangYuchao Chen
Mar 6, 2021·Current Opinion in Neurology·Frank G GilliamMatthew S Gentry
Aug 20, 2021·Autonomic Neuroscience : Basic & Clinical·Smriti PatodiaMaria Thom

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